AChE-IN-119
AChE-IN-119 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.0641 μM and a Ki of 0.01648 μM. AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals. AChE-IN-119 exhibits mixed-type inhibition and interacts with both the catalytic active site and the peripheral anionic site of acetylcholinesterase. AChE-IN-119 can be used for the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C20H13ClN4O2S
- Molecular Weight:408.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
AChE 0.01648 μM (Ki) |
AChE 0.0641 μM (IC50) |
In Vitro
AChE-IN-119 (compound 4) potently inhibits purified acetylcholinesterase (AChE) via a mixed-type inhibition mechanism, with an IC50 of 0.0641 μM. It exhibits 108-fold higher selectivity for AChE over butyrylcholinesterase (BChE), and its Ki value against AChE is 0.01648 μM[1].
AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals, with an IC50 of 10.01 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 408.86
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Formula C20H13ClN4O2S
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SMILES
CN(C1=CC=C(Cl)C=C1/C2=N/NC3=NC=C(C4=CC(C=CC=C5)=C5O4)S3)C2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-119 Related Classifications
HY-184796 Related Classifications
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