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United States

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製品番号: HY-184907

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AI10-m15

AI10-m15 is a tyrosinase inhibitor, with IC₅₀ values of 0.019 μM (using L-DOPA (HY-N0304) as the substrate) and 0.02 μM (using L-Tyrosine (HY-N0473) as the substrate) against mushroom tyrosinase. AI10-m15 inhibits intracellular melanin production and reduces head pigmentation in zebrafish embryos. AI10-m15 can be used for the research of hyperpigmentation disorders.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₉H₂₀N₂O₄
分子量:340.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AI10-m15 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

AI10-m15 (concentration gradient) exhibits improved cellular safety with a maximum nontoxic concentration of 100 μM in A375, B16F10, HEM, and HaCaT cells^[1].
AI10-m15 (12.5-100 μM) potently inhibits intracellular melanogenesis in B16F10 cells, with greater efficacy than kojic acid and β-arbutin across tested concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

AI10-m15 (30-60 μM; exposure for 45 h) exhibits potent in vivo anti-melanogenic activity in zebrafish embryos, achieving a depigmentation rate of 20.93% at a concentration of 60 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

wild-type AB strain (6 hours postfertilization embryos)^[1]
Dosage:

30 μM; 60 μM
Administration:

exposure; 45 hours
Result:

Achieved a depigmentation efficacy of 20.93% at 60 μM, significantly reducing head melanophore signal intensity compared to the control group.
Showed measurable antimelanogenic activity with minimal toxicity at 30 μM.

化学情報

分子量 340.37
分子式 C₁₉H₂₀N₂O₄
SMILES

O=C(N1CCN(CC1)C2=CC=C(C=C2)O)/C=C/C3=C(C=C(C=C3)O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pizzorno J, et al. Health Medicine. Integrative medicine (Encinitas, Calif.). 2022 Dec;21(6):8-14. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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