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Cat. No.: HY-184907

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AI10-m15

AI10-m15 is a tyrosinase inhibitor, with IC₅₀ values of 0.019 μM (using L-DOPA (HY-N0304) as the substrate) and 0.02 μM (using L-Tyrosine (HY-N0473) as the substrate) against mushroom tyrosinase. AI10-m15 inhibits intracellular melanin production and reduces head pigmentation in zebrafish embryos. AI10-m15 can be used for the research of hyperpigmentation disorders.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₀N₂O₄
Molecular Weight:340.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AI10-m15 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

AI10-m15 (concentration gradient) exhibits improved cellular safety with a maximum nontoxic concentration of 100 μM in A375, B16F10, HEM, and HaCaT cells^[1].
AI10-m15 (12.5-100 μM) potently inhibits intracellular melanogenesis in B16F10 cells, with greater efficacy than kojic acid and β-arbutin across tested concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AI10-m15 (30-60 μM; exposure for 45 h) exhibits potent in vivo anti-melanogenic activity in zebrafish embryos, achieving a depigmentation rate of 20.93% at a concentration of 60 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

wild-type AB strain (6 hours postfertilization embryos)^[1]
Dosage:

30 μM; 60 μM
Administration:

exposure; 45 hours
Result:

Achieved a depigmentation efficacy of 20.93% at 60 μM, significantly reducing head melanophore signal intensity compared to the control group.
Showed measurable antimelanogenic activity with minimal toxicity at 30 μM.

Chemical Information

Molecular Weight 340.37
Formula C₁₉H₂₀N₂O₄
SMILES

O=C(N1CCN(CC1)C2=CC=C(C=C2)O)/C=C/C3=C(C=C(C=C3)O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pizzorno J, et al. Health Medicine. Integrative medicine (Encinitas, Calif.). 2022 Dec;21(6):8-14. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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