2. PI3K/Akt/mTOR Autophagy Neuronal Signaling Anti-infection
  3. Akt Autophagy PTEN Amyloid-β Antibiotic Bacterial Fungal
  4. Alborixin

Alborixin is a polycyclic polyether ionophore Antibiotic. Alborixin is isolated from cultures of Streptomyces albus. Alborixin induces Autophagy via PTEN-mediated inhibition of the AKT pathway, thereby clearing Amyloid-β. Alborixin exhibits activity against Gram-positive bacteria and fungi. Alborixin can be used in the research of Alzheimer's disease.

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Alborixin

Alborixin 화학구조

CAS No. : 57760-36-8

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Alborixin Related Antibodies

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제품 설명

Alborixin is a polycyclic polyether ionophore Antibiotic. Alborixin is isolated from cultures of Streptomyces albus. Alborixin induces Autophagy via PTEN-mediated inhibition of the AKT pathway, thereby clearing Amyloid-β. Alborixin exhibits activity against Gram-positive bacteria and fungi. Alborixin can be used in the research of Alzheimer's disease[1][2].

In Vitro

Alborixin (30-125 nM; 3-24 h) induces autophagy in mouse microglial N9 cells, with the maximal effect observed after treatment with 125 nM for 24 h; its mechanism of action involves upregulating LC3B-II levels, downregulating SQSTM1 levels, promoting GFP-LC3 puncta formation and increasing the number of autophagosomes[1].
Alborixin (125 nM) enhances soluble and fibrillar Aβ-induced autophagy in mouse microglial N9 cells, as evidenced by increased LC3B-II levels and decreased SQSTM1 levels[1].
Alborixin (125-250 nM; 12-24 h) eliminates soluble Aβ and fibrillary Aβ in mouse microglial N9 cells and human microglial HMC3 cells, and clears soluble Aβ in primary mouse neurons at 250 nM for 24 h. Its mechanism of action relies on the PTEN-AKT-dependent autophagy pathway, which requires functional ATG5 and BECN1[1].
Alborixin exhibits activity against Gram-positive bacteria and fungi[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alborixin Related Antibodies

Cell Autophagy Assay[1]

Cell Line: mouse microglial N9 cells
Concentration: 30 nM; 125 nM
Incubation Time: 12 h; 3 h, 6 h, 12 h, 24 h
Result: Induced autophagy in a concentration-dependent manner, with increased LC3B-II levels and decreased SQSTM1 levels detectable at 30 nM for 12 h.
Increased LC3B-II:ACTB ratio in a time-dependent manner at 125 nM for 3 h, 6 h, 12 h, 24 h, while decreasing SQSTM1:ACTB ratio.
Confirmed autophagy flux via further increases in LC3B-II levels when combined with bafilomycin A1.
Increased GFP-LC3 puncta per cell.
Increased average autophagosomes per cell.

Western Blot Analysis[1]

Cell Line: mouse microglial N9 cells
Concentration: 125 nM
Incubation Time: 3 h, 6 h, 9 h, 12 h, 24 h
Result: Upregulated autophagy-related proteins BECN1, ATG7, ATG5, and ATG12 in a time-dependent manner, with peak expression at 24 h.
Increased PTEN:ACTB ratio in a time-dependent manner.
Reduced the ratios of p-AKT (S473):AKT, p-AKT (T308):AKT, p-MTOR (S2448):MTOR, and RPTOR:ACTB over 24 h.
분자량

885.17

화학식

C48H84O14
CAS No.
SMILES

O[C@@]1([C@]2(O[C@](CC2)([H])[C@H]([C@@]3(O[C@@H]([C@H](C[C@H]3C)C)C[C@]4(O[C@@](CC[C@@H]4C)([H])[C@@H](C)[C@H](O)C[C@@H]5O[C@]([C@H](C[C@H]5C)C)([H])[C@@H](C)C(O)=O)O)O)O)C)O[C@@](C[C@H]1C)([C@]6([H])O[C@H]([C@](O)(CC6)C)CC)C
Structure Classification
Initial Source

streptomyces scabrisporus
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Alborixin Related Classifications

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Keywords:

Alborixin57760-36-8AktAutophagyPTENAmyloid-βAntibioticBacterialFungalPKBProtein kinase BPhosphatase and tensin homologMMAC1β-amyloid peptideAβAbetaBECN1/Beclin 1ATG7PI3K-AKT pathwaymicrogliaalzheimer diseaseATG5amyloid-βneuronsautophagyInhibitorinhibitorinhibit

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Alborixin
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HY-167843
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