ALK5-IN-33
ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM.
For research use only. We do not sell to patients.
- CAS No.: 2785430-89-7
- Formula: C23H23N7O
- Molecular Weight:413.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ALK5 ≤10 nM (IC50) |
ALK2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic nude mice, A549 xenograft model[1]
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Dosage:10, 50, 75 and 100 mg/kg
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Administration:Oral gavage, once
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Result:Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.
Chemical Information
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CAS No. 2785430-89-7
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Molecular Weight 413.48
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Formula C23H23N7O
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SMILES
CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCOCC5)C=C4)=NC=C3)C=NN=C12
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALK5-IN-33 Related Classifications
HY-151283 Related Classifications
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