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  3. Allylthiourea

Allylthiourea (Synonyms: Thiosinamine; N-Allylthiourea)

Cat. No.: HY-B0543 Purity: >99.0%
Handling Instructions

Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.

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Allylthiourea Chemical Structure

Allylthiourea Chemical Structure

CAS No. : 109-57-9

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Description

Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation. Target: Others Allylthiourea selectively inhibits ammonia oxidation at concentrations 8-80 μM. Allylthiourea (1 μM)inhibits ammonia oxidation by 80%. Complete inhibition is observed at an Allylthiourea concentration of 86 μM [1]. The inhibition of Allylthiourea on ammonia oxidation probably acts through chelating the copper of the ammonia monooxygenase active site. Allylthiourea is able to produce soluble methane monooxygenase (sMMO) in the presence of copper. Addition of 25 μM Allylthiourea decreases intracellular copper by 48% in Methylosinus trichosporium OB3b, allowing sMMO production at Cu/biomass ratios normally not permitting sMMO synthesis, which achieves a plateau of 320 μmol naphthol formed per gram dry biomass per hour [2].

Molecular Weight

116.18

Formula

C₄H₈N₂S

CAS No.

109-57-9

SMILES

S=C(N)NCC=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (860.73 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.6073 mL 43.0367 mL 86.0733 mL
5 mM 1.7215 mL 8.6073 mL 17.2147 mL
10 mM 0.8607 mL 4.3037 mL 8.6073 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (21.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (21.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (21.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AllylthioureaThiosinamine N-AllylthioureaReactive Oxygen SpeciesInhibitorinhibitorinhibit

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Allylthiourea
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