Almotriptan hydrochloride-d6
Based on 1 Customer Validation
Almotriptan-d6 (PNU180638-d6) hydrochloride is the deuterium labeled Almotriptan hydrochloride. Almotriptan hydrochloride is an orally active, highly selective agonist of the 5-HT1B/1D receptor (5-HT1B/1D receptor), with EC50 values of 1.6 nM and 3.1 nM, respectively. Almotriptan hydrochloride shows moderate affinity for the 5-HT1F receptor, and weak affinity for the 5-HT1A, 5-HT6 and 5-HT7 receptors. Almotriptan hydrochloride induces intracranial vasoconstriction, inhibits nociceptive neurotransmission in the trigeminocervical complex, and suppresses the release of vasoactive peptides from trigeminal nerve endings. Almotriptan hydrochloride can be used in research related to migraine.
For research use only. We do not sell to patients.
- Purity: 97.30%
- CAS No.: 1794782-57-2
- Formula: C17H20D6ClN3O2S
- Molecular Weight:377.96
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1794782-57-2
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Unlabeled Cas 154323-46-3
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Appearance Solid
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Molecular Weight 377.96
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Formula C17H20D6ClN3O2S
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Color Off-white to light yellow
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SMILES
[2H]C([2H])([2H])N(C([2H])([2H])[2H])CCC(C1=C2)=CNC1=CC=C2CS(=O)(N3CCCC3)=O.Cl
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Synonyms
PNU180638 hydrochloride-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Pascual J, et al. Almotriptan: a review of 20 years' clinical experience. Expert Rev Neurother. 2019;19(8):759-768. [Content Brief]
[3]. Gras J, et al. Almotriptan, a new anti-migraine agent: a review. CNS Drug Rev. 2002;8(3):217-234. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Almotriptan hydrochloride-d6 Related Classifications
HY-B0383AS Related Classifications
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