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Referencia número: HY-FL14188

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Amiodarone hydrochloride solution

Amiodarone hydrochloride solution is mainly composed of Amiodarone hydrochloride (HY-14188). Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outward ionic current (IhERG) tails with an IC₅₀ of ∼45 nM. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias.

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No. CAS: 19774-82-4
Fòrmula: C₂₅H₃₀ClI₂NO₃
Peso molecular:681.77

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Please store the product under the recommended conditions in the Certificate of Analysis.

Amiodarone hydrochloride solution Chemical Structure

No. CAS: 19774-82-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Amiodarone hydrochloride solution is mainly composed of Amiodarone hydrochloride (HY-14188). Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outward ionic current (IhERG) tails with an IC₅₀ of ∼45 nM^[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts^[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias^[1].

Chemical Information

No. CAS 19774-82-4
Peso molecular 681.77
Fòrmula C₂₅H₃₀ClI₂NO₃
SMILES

CCCCC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=C(O1)C=CC=C3.Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yihong Zhang,et al. Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. Biochem Pharmacol. 2016 Aug 1;113:24-35. [Content Brief]

[2]. Jie Weng, et al. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Biomed Pharmacother. 2019 Jul;115:108889. [Content Brief]

[3]. Sabrina Le Bouter, et al. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation. 2004 Nov 9;110(19):3028-35. [Content Brief]

[4]. Punithavathi D, et al. Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats. Br J Pharmacol. 2003 Aug;139(7):1342-50. [Content Brief]

[5]. Shayeganpour A, et al. Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat-meal rat models. Biopharm Drug Dispos. 2005 Sep;26(6):249-57. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Amiodarone hydrochloride solution

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Amiodarone hydrochloride solution

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Amiodarone hydrochloride solution Related Classifications

HY-FL14188 Related Classifications

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