(4S)-Anthelvencin
(4S)-Anthelvencin is a pyrrolamide metabolite with moderate antibacterial and anthelmintic activities.
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- CAS No.: 58616-25-4
- Formule: C19H25N9O3
- Masse moléculaire:427.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | EC50 |
88 μM
Compound: 4a
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Inhibitory activity against HIV-1 in T4-lymphocytes (CEM cell line).
Inhibitory activity against HIV-1 in T4-lymphocytes (CEM cell line).
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[PMID: 1322989] |
| CCRF-CEM | IC50 |
750 μM
Compound: 4a
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Inhibition of T4-lymphocytes (CEM cell line) infected with HIV-1.
Inhibition of T4-lymphocytes (CEM cell line) infected with HIV-1.
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[PMID: 1322989] |
Chemical Information
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CAS No. 58616-25-4
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Masse moléculaire 427.46
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Formule C19H25N9O3
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SMILES
N=C(N)CCNC(C1=CC(NC(C2=CC(NC([C@H]3N=C(CC3)N)=O)=CN2)=O)=CN1C)=O
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Structure Classification
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Initial Source
Streptomyces venezuelae ATCC 14583 and 14585
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(4S)-Anthelvencin Related Classifications
HY-169507 Related Classifications
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