2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 136

Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM; HY-15230), has an IC50 of 3.38 μM for HDF and a Kd of 3.86 μM for Hsp90. Anticancer agent 136 is an apoptosis-inducing agent.

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Anticancer agent 136

Anticancer agent 136 Chemical Structure

CAS No. : 3049419-74-8

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Description

Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM; HY-15230), has an IC50 of 3.38 μM for HDF and a Kd of 3.86 μM for Hsp90. Anticancer agent 136 is an apoptosis-inducing agent[1].

Cellular Effect
Cell Line Type Value Description References
NHDF IC50
3.38 μM
Compound: 22
Cytotoxicity against human HDF cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
Cytotoxicity against human HDF cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
[PMID: 37210951]
PC-3 IC50
1.11 μM
Compound: 22
Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
[PMID: 37210951]
SK-BR-3 IC50
1.16 μM
Compound: 22
Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
[PMID: 37210951]
SK-OV-3 IC50
1.08 μM
Compound: 22
Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
[PMID: 37210951]
Molecular Weight

742.86

Formula

C40H50N6O8
CAS No.
SMILES

O=C1C(NCC2=CN(C/C=C/C3=CC=CC=C3)N=N2)=C4C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C4)=O)=C1)=O
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Purity & Documentation
References
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Anticancer agent 136 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1363049419-74-8Anticancer agent136Anticancer agent-136ApoptosisHDFHsp90Inhibitorinhibitorinhibit

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