Anticancer agent-376
Anticancer agent-376 is a hydroxyethyl-substituted benzimidazolium salt with antiproliferative activity against cancer cell lines. Anticancer agent-376 inhibits MDA‑MB‑231, 4T1, HT‑29, and DLD‑1 tumor cells, with corresponding IC50 values of 8.7 µM, 10.2 µM, 28.6 µM, and 43.4 µM, respectively. Anticancer agent-376 can be used in research related to cancers such as breast cancer and colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 2379553-99-6
- Formula: C21H27BrN2O
- Molecular Weight:403.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
80.64 μM
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Antiproliferative activity against human HeLa cervical cancer cells assessed as viability reduction by MTT assay.
Antiproliferative activity against human HeLa cervical cancer cells assessed as viability reduction by MTT assay.
|
preprints202602.0586.v1 |
| MDA-MB-231 | IC50 |
7.59 μM
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Antiproliferative activity against human MDA-MB-231 breast cancer cells assessed as viability reduction by MTT assay.
Antiproliferative activity against human MDA-MB-231 breast cancer cells assessed as viability reduction by MTT assay.
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preprints202602.0586.v1 |
| MDA-MB-231 | IC50 |
8.7 μM
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Antiproliferative activity against human MDA-MB-231 breast cancer cells assessed as viability reduction incubated 72 hrs by MTT assay.
Antiproliferative activity against human MDA-MB-231 breast cancer cells assessed as viability reduction incubated 72 hrs by MTT assay.
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preprints202602.0586.v1 |
| 4T1 | IC50 |
10.2 μM
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Antiproliferative activity against mouse 4T1 breast cancer cells assessed as viability reduction incubated 72 hrs by MTT assay.
Antiproliferative activity against mouse 4T1 breast cancer cells assessed as viability reduction incubated 72 hrs by MTT assay.
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preprints202602.0586.v1 |
| HT-29 | IC50 |
28.6 μM
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Antiproliferative activity against human HT-29 colorectal cancer cells assessed as viability reduction incubated 72 hrs by MTT assay.
Antiproliferative activity against human HT-29 colorectal cancer cells assessed as viability reduction incubated 72 hrs by MTT assay.
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preprints202602.0586.v1 |
| DLD-1 | IC50 |
43.4 μM
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Antiproliferative activity against human DLD-1 colorectal cancer cells assessed as viability reduction incubated 72 hrs by MTT assay.
Antiproliferative activity against human DLD-1 colorectal cancer cells assessed as viability reduction incubated 72 hrs by MTT assay.
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preprints202602.0586.v1 |
In Vitro
Anticancer agent-376 shows the strongest activity in MDA-MB-231 (IC50 8.7 µM) and 4T1 (10.2 µM) breast cancer cells, and weaker activity in HT-29 (28.6 µM) and DLD-1 (43.4 µM) colorectal cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2379553-99-6
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Molecular Weight 403.36
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Formula C21H27BrN2O
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SMILES
OCCN1C=[N+](CC2=C(C)C(C)=C(C)C(C)=C2C)C3=C1C=CC=C3.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent-376 Related Classifications
HY-186399 Related Classifications
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