Anticancer agent 49 

Anticancer agent 49 (compound 69) is a broad spectrum anticancer agent. Anticancer agent 49 inhibits tubulin polymerization. Anticancer agent 49 shows antiproliferative activity. Anticancer agent 49 has the potential for the research of solid and hematological tumors^[1].

Anticancer agent 49 (compound 69) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC₅₀s of 0.38 µM and 15 nM, respectively^[1].
Anticancer agent 49 shows antiproliferative activity with IC₅₀s of 5, 8, 10, 10, 12 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively^[1].
Anticancer agent 49 shows growth inhibition with IC₅₀s of 22, 48, 24, 303, 147, 41, 34, 153, 61, 58 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

443.49

C₂₆H₂₅N₃O₄

2395009-34-2

COC1=CC(C(C2=CN(C=C2C3=CC=C(C=C3)N)C4=CC=C(C=C4)N)=O)=CC(OC)=C1OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Puxeddu M, et al. Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies. Eur J Med Chem. 2020 Jan 1;185:111828.  [Content Brief]