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Cat. No.: HY-151501

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Antimicrobial agent-11

Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity.

For research use only. We do not sell to patients.

Formula: C₇₇H₆₁Cl₂F₁₇N₈O₂₄
Molecular Weight:1876.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Antimicrobial agent-11 Chemical Structure

Size

Price

Stock

Quantity

Sample (0.1mg)

In-stock

(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity^[1].

IC₅₀ & Target

Bacteria, SARS-CoV-2^[1]

In Vitro

Antimicrobial agent-11 (compound 5) shows inhibitory activity on coronavirus (SARS-CoV-2) replication and spike-mediated pseudovirus entry in Vero E6 cells and Calu-3 cells, with EC₅₀ values of 24 μM, 57μM^[1].
Antimicrobial agent-11 inhibits Cathepsin L, 3CL^Pro enzyme activity and the ACE2-spike interaction, with EC₅₀ values of 52 μM, 5 μM and 65 μM respectively^[1].
Antimicrobial agent-11 (0-10 μg/mL approximately) shows activity against diverse species of Gram-positive bacteria^[1].
Antimicrobial agent-11 (0-100 μM, 2 h) inhibits SARS-CoV-2 pseudovirus entry in Vero and A549-AT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

S. aureus, E. faecalis, E. faecium, S. epidermidis, S. haemolyticus
Concentration:

0-1 μg/mL approximately
Incubation Time:
Result:

Inhibited bacteria activities with MIC values of 0.25-7 μg/mL.

Chemical Information

Molecular Weight 1876.23
Formula C₇₇H₆₁Cl₂F₁₇N₈O₂₄
SMILES

OC1=C(OC2=C(C=C(C=C2)[C@@]([H])(O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(C)=O)[C@]([H])(NC([C@@H]4N5)=O)C(N[C@H](C6=CC(O)=CC(O)=C6C7=CC4=CC=C7O)C(O)=O)=O)Cl)C=C(C=C1OC8=C(C=C(C=C8)C[C@]([H])9NC([C@@H]%10NC(CCC(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)C(F)(C(F)(F)F)F)F)F)F)F)F)=O)=O)Cl)[C@H](C5=O)NC([C@@H](NC9=O)C%11=CC(OC%12=CC%10=CC=C%12O)=CC(O)=C%11)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ilona Bereczki, et al. Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria. Sci Rep. 2022 Sep 26;12(1):16001. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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