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Cat. No.: HY-189049

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Antiparasitic agent-47

Antiparasitic agent-47 is a nitroimidazole derivative with potent antiparasitic activity. Antiparasitic agent-47 exhibits IC₅₀ values of 0.72 μM and 9.33 μM against sensitive and drug-resistant strains of Trichomonas vaginalis, respectively. Antiparasitic agent-47 can be used in research related to trichomoniasis.

For research use only. We do not sell to patients.

CAS No.: 1214752-97-2
Formula: C₁₁H₁₆N₄O₂S₂
Molecular Weight:300.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antiparasitic agent-47 Chemical Structure

CAS No.: 1214752-97-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	CC₅₀	338.4 μM	Cytotoxicity against human cervical adenocarcinoma epithelial HeLa cells assessed via MTT assay after 48 h incubation. Cytotoxicity against human cervical adenocarcinoma epithelial HeLa cells assessed via MTT assay after 48 h incubation.	42569176

In Vitro

Antiparasitic agent-47 (compound 3a) (up to 100 μM; 24 h) potently inhibits the activity of T. vaginalis, with an IC₅₀ of 0.72 μM against the T. vaginalis JT strain and an IC₅₀ of 9.33 μM against the T. vaginalis CDC085 strain^[1].
Antiparasitic agent-47 (12.5-400 μM; 48 h) exhibits almost no cytotoxicity against HeLa cells (CC₅₀ = 338.4 μM), demonstrating favorable safety^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa cells
Concentration:

12.5, 25, 50, 100, 200, 400 μM
Incubation Time:

48 h
Result:

Exhibited very low cytotoxicity, with a CC₅₀ value of 338.4 μM.

Chemical Information

CAS No. 1214752-97-2
Molecular Weight 300.40
Formula C₁₁H₁₆N₄O₂S₂
SMILES

CC1=NC=C(N1CCSC(N2CCCC2)=S)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Veríssimo GC,et al. Machine Learning Classification Models for the Design of Novel Nitroimidazole Derivatives with Anti-Trichomonas vaginalis Activity. ACS Omega. 2026 Jul 23;11(30):45515-45527.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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