1. Anti-infection
  2. Bacterial
  3. Antitubercular agent-31

Antitubercular agent-31 

Cat. No.: HY-151339
Handling Instructions

Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM.

For research use only. We do not sell to patients.

Antitubercular agent-31 Chemical Structure

Antitubercular agent-31 Chemical Structure

CAS No. : 2764818-29-1

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Description

Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM[1].

IC50 & Target

IC50: 1.1 μM (DprE1)[1]

In Vitro

Antitubercular agent-31 (Compound 2) shows aqueous solubility of 0.81 μg/mL in phosphate buffer pH 7.4. The plasma protein binding property is 97.9%[1].
Antitubercular agent-31 shows acceptable liver microsomal stability in human and mouse liver microsomes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitubercular agent-31 (10 or 2 mg/kg; p.o. or i.v.; once) displays an acceptable pharmacokinetics (PK) profile with only dosing i.v., shows either poor membrane permeability or rapid clearance rate in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c mice[1]
Dosage: 10 mg/kg or 2 mg/kg
Administration: Oral (10 mg/kg) or intravenous (2 mg/kg) administration (Pharmacokinetic Analysis)
Result: PK data for Antitubercular agent-31 (Compound 2),iv, 2mg/kg[1].
Tmax (h) Cmax (ng/mL) AUC0-t
(h*ng/mL)
AUC0-∞
(h*ng/mL)
T1/2 (h) CL/F
(mL/h/kg)
MRT0-∞
(h)
0.1±0.0 463.4±103.4 158.2±18.8 161.3±18.6 0.3±0.0 12515.5±1379.7 0.4±0.0

No compound signal was detected at oral administration.
Molecular Weight

502.56

Formula

C20H24F2N4O5S2

CAS No.
SMILES

O=C1N=C(N2CCN(CC3CCC(F)(F)CC3)CC2)SC4=C([N+]([O-])=O)C=C(S(=O)(C)=O)C=C14

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antitubercular agent-31
Cat. No.:
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