Asn-Trp TFA

BALB/c (male, 10 weeks old)^[1]

10 mg/kg/day; 40 mg/kg/day

p.o.; daily; 4 weeks

Plasma MDA at 8 weeks was lower in the 10 mg/kg/day and 40 mg/kg/day groups than in the Gal group.
In the Morris water maze reference memory task, 40 mg/kg/day reduced latency to reach the platform compared with Gal, with latency comparable to blank; 10 mg/kg/day did not.
Swimming speed was comparable across groups.
In the probe trial, 40 mg/kg/day increased crossings in the target quadrant compared with Gal, with crossings comparable to blank; 10 mg/kg/day did not.
Brain GSH was elevated by 40 mg/kg/day versus Gal; liver GSH was elevated by 10 mg/kg/day and 40 mg/kg/day versus Gal.
Brain MDA was reduced by 10 mg/kg/day and 40 mg/kg/day versus Gal and was comparable to blank; liver MDA was reduced by 40 mg/kg/day versus Gal.
ORAC activity in brain and liver tissues was elevated by 10 mg/kg/day and 40 mg/kg/day versus Gal.
40 mg/kg/day reduced argpyrimidine-modified AGEs in brain tissue versus Gal; 10 mg/kg/day and 40 mg/kg/day reduced CML-modified AGEs in brain tissue versus Gal, comparable to blank.