Asperilin
Asperilin (NSC 85238) is an orally active sesquiterpene lactone. Asperilin depletes hepatic glutathione in vivo, induces hepatic microsomal lipid peroxidation, elevates glutathione peroxidase activity, and mildly increases plasma AST and ALT. Asperilin scavenges hydroxyl radicals. Asperilin shows anticancer activity against melanoma.
For research use only. We do not sell to patients.
- CAS No.: 7044-35-1
- Formula: C15H20O3
- Molecular Weight:248.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
17.6 μM
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Cytotoxicity against human melanoma A375 cells in an in vitro cell-based assay.
Cytotoxicity against human melanoma A375 cells in an in vitro cell-based assay.
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5674 |
| WM793 | IC50 |
28.2 μM
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Cytotoxicity against human melanoma WM793 cells in an in vitro cell-based assay.
Cytotoxicity against human melanoma WM793 cells in an in vitro cell-based assay.
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5674 |
| Hs 294T | IC50 |
29.5 μM
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Cytotoxicity against human melanoma Hs 294T cells in an in vitro cell-based assay.
Cytotoxicity against human melanoma Hs 294T cells in an in vitro cell-based assay.
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5674 |
In Vitro
Asperilin (1 h) scavenges hydroxyl radicals in the cell-free deoxyribose assay with a rate constant of 8.9-10.6 × 109 mol-1 s-1[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar (male, 150 g)[4]
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Dosage:2.5 mg/kg b.w.
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Administration:i.g.; single administration; 19 h after administration
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Result:Fe2+/ascorbate-induced microsomal lipid peroxidation was 37.94 nmol MDA × min-1 × mg-1 protein.
Fe3+/ADP/NADPH-induced microsomal lipid peroxidation was 20.28 nmol MDA × min-1 × mg-1 protein.
CCl4/NADPH-induced microsomal lipid peroxidation was 31.67 nmol MDA × min-1 × mg-1 protein.
Uninduced microsomal lipid peroxidation was 4.31 nmol MDA × min-1 × mg-1 protein.
Liver GSH level was 4.00 nmol × mg-1 protein.
Liver cytosol GPx activity was 142.82 U × mg-1 protein.
Serum ALT activity was 50.85 U × mL-1.
Serum AST activity was 72.03 U × mL-1.
Chemical Information
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CAS No. 7044-35-1
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Molecular Weight 248.32
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Formula C15H20O3
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SMILES
C[C@]12[C@@](C(CC[C@H]2O)=C)([H])C[C@@]3([H])[C@@](OC(C3=C)=O)([H])C1
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Synonyms
NSC 85238
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Asperilin Related Classifications
HY-N16658 Related Classifications
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Keywords
- Asperilin
- 7044-35-1
- NSC 85238
- NSC85238
- NSC-85238
- Glutathione Peroxidase
- Aminotransferases (Transaminases)
- Free Radical Scavengers
- antiproliferative activity
- catalase
- glutathione peroxidase
- hepatic glutathione depletion
- hepatotoxicity
- hydroxyl radical scavenger
- lipid peroxidation
- melanoma
- pro-oxidative inducer
- superoxide dismutase
- Inhibitor
- inhibitor
- inhibit