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Art. -Nr.: HY-112444

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BACE1-IN-2

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC₅₀ of 22 nM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1352416-78-4
Formel: C₁₉H₁₅F₄N₅O₂
Molecular Weight:421.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BACE1-IN-2 Chemical Structure

CAS. Nr.: 1352416-78-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC₅₀ of 22 nM^[1].

IC₅₀ & Target

BACE1

Alle Beta-secretase Isoform-spezifische Produkte anzeigen :

BACE1
BACE2

In Vitro

BACE1-IN-2 (Compound 3) is 10-fold more potent toward BACE1 than BACE2, inhibition of which may lead to hair depigmentation. BACE1-IN-2 inhibits hAβ42 cell with an IC₅₀ of 6.0 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1352416-78-4
Molecular Weight 421.35
Formel C₁₉H₁₅F₄N₅O₂
SMILES

NC1=N[C@@](C2=C(F)C=CC(NC(C3=CC=C(C#N)C=N3)=O)=C2)(C)[C@H](C(F)(F)F)OC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gijsen HJM, et al. Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. J Med Chem. 2018 Jun 28;61(12):5292-5303. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
Menge:
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BACE1-IN-2

Verubecestat

LY2886721

Lanabecestat

LY2811376

AZD3839 free base

Elenbecestat

BACE1-IN-1

Verubecestat (Standard)

LY2811376 (Standard)

Elenbecestat (Standard)

BACE1-IN-1 (Standard)

Lanabecestat (Standard)

Alle Beta-secretase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bioz

BACE1-IN-2

Verubecestat

LY2886721

Lanabecestat

LY2811376

AZD3839 free base

Elenbecestat

BACE1-IN-1

Verubecestat (Standard)

LY2811376 (Standard)

Elenbecestat (Standard)

BACE1-IN-1 (Standard)

Lanabecestat (Standard)

Alle Beta-secretase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BACE1-IN-2 Related Classifications

HY-112444 Related Classifications

Bioz