Art. -Nr.: HY-B0935

Benzyl benzoate

(Synonyms: Phenylmethyl benzoate)

1 Cited Publications

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Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC₅₀= 0.06 g/m²) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.

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Reinheit: 99.98%
CAS. Nr.: 120-51-4
Formel: C₁₄H₁₂O₂
Molecular Weight:212.25

Speicherung:

RT, protect from light.

In solvent -80°C, 1 year , -20°C, 6 months

Benzyl benzoate Chemical Structure

CAS. Nr.: 120-51-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Mite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Alle Parasite Isoform-spezifische Produkte anzeigen :

Alle Angiotensin Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	107.2 μg/mL Compound: 1	Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracellular calcium uptake Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracellular calcium uptake	[PMID: 18672373]

In Vitro

Benzyl benzoate (10000-50000 mg/L; 72 h) has toxic effects in allium root cells^[3].
Benzyl benzoate (10-100 μM; 1-200 s) inhibits Ang II activity in a dose-dependent manner in 293T cells of human embryonic kidney epithelium (mAT1a(HA)/293T) (IC₅₀=107 μg/mL) without cytotoxicity^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benzyl benzoate (25-100 mg/kg; p.o.; Once daily for 90 days) has no significant effects on body weight, relative organ weight, hematology, and biochemical outcomes in rats, but causes pathological changes in liver, kidney, thymus, prostate, and epididymal tissues in Sprague Dawley rats^[4].
Benzyl benzoate (2-10 mg/kg; p.o.; Single dose) significantly inhibits Ang II (100 μg/kg) -induced hypertension in Std:ddY mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Hypertensive male Std:ddY mice model^[5]
Dosage:

2 mg/kg, 10 mg/kg
Administration:

Oral gavage (p.o.); Single dose. Before Ang II treatment (100 μg/kg; Intraperitoneal injection (i.p.); Single dose)
Result:

Significantly inhibited the rise in systolic blood pressure induced by Ang II treatment.

Animal Model:

Sprague Dawley male rats model^[4]
Dosage:

25 mg/kg, 100 mg/kg
Administration:

Oral gavage (p.o.); Once daily for 90 days
Result:

Induced hepatic portal vein blood supply, sinusoid sinus enlargement, monocyte infiltration, local lysis and cytoplasmic degeneration in rats.
Induced renal tissue congestion, renal tubule degeneration, monocyte infiltration and histolysis in rats. Resulted in increased number of Hassall’s bodies, elevated lipids, degeneration, congestion, fibrosis and lymphocytopenia in the thymus of rats.
Resulted in vacuolation and irregular secretion of the prostate in male reproductive system tissue, increased connective tissue of the epididymis and presence of cells in the lumen.
In the male reproductive system tissues, resulted in vacuolation and irregular secretion in the prostate, increased connective tissue of the epididymis, and presence of cells in the lumen.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 120-51-4
Appearance Liquid (Density: 1.118 g/cm³)
Molecular Weight 212.25
Formel C₁₄H₁₂O₂
Color Colorless to light yellow
SMILES

O=C(OCC1=CC=CC=C1)C2=CC=CC=C2
Synonyms

Phenylmethyl benzoate
Structure Classification
- Others
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

RT, protect from light

In solvent	-80°C	1 year
	-20°C	6 months

Publications (1)

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Journal Impact Factor

Int J Polym Anal Ch

2021 Jan 7.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 200 mg/mL (942.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.7114 mL

23.5571 mL

47.1143 mL

5 mM

0.9423 mL

4.7114 mL

9.4229 mL

10 mM

0.4711 mL

2.3557 mL

4.7114 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bachewar NP, et al. Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. Indian J Pharmacol. 2009 Feb;41(1):9-14. [Content Brief]

[2]. Raynaud S, et al. Squamocin and benzyl benzoate, acaricidal components of Uvaria pauci-ovulata bark extracts. Planta Med. 2000 Mar;66(2):173-5. [Content Brief]

[3]. Acar A, et al. Investigation of benzyl benzoate toxicity with anatomical, physiological, cytogenetic and biochemical parameters in in vivo[J]. Caryologia, 2020, 73(3).

[4]. Kılıç Süloğlu A, et al. Toxicity of benzyl benzoate as a food additive and pharmaceutical agent. Toxicol Ind Health. 2022 Apr;38(4):221-233. [Content Brief]

[5]. Ohno O, et al. Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension. Bioorg Med Chem. 2008 Aug 15;16(16):7843-52. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.7114 mL	23.5571 mL	47.1143 mL	117.7856 mL
	5 mM	0.9423 mL	4.7114 mL	9.4229 mL	23.5571 mL
	10 mM	0.4711 mL	2.3557 mL	4.7114 mL	11.7786 mL
	15 mM	0.3141 mL	1.5705 mL	3.1410 mL	7.8524 mL
	20 mM	0.2356 mL	1.1779 mL	2.3557 mL	5.8893 mL
	25 mM	0.1885 mL	0.9423 mL	1.8846 mL	4.7114 mL
	30 mM	0.1570 mL	0.7852 mL	1.5705 mL	3.9262 mL
	40 mM	0.1178 mL	0.5889 mL	1.1779 mL	2.9446 mL
	50 mM	0.0942 mL	0.4711 mL	0.9423 mL	2.3557 mL
	60 mM	0.0785 mL	0.3926 mL	0.7852 mL	1.9631 mL
	80 mM	0.0589 mL	0.2945 mL	0.5889 mL	1.4723 mL
	100 mM	0.0471 mL	0.2356 mL	0.4711 mL	1.1779 mL

Keywords

Benzyl benzoate

1 Cited Publications

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Benzyl benzoate

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Publications Citing Use of MedChemExpress (MCE) Benzyl benzoate

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Alle Parasite Isoform-spezifische Produkte anzeigen

Alle Angiotensin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Benzyl benzoate Related Classifications

HY-B0935 Related Classifications