COH000
Based on 2 publication(s) in Google Scholar
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro.
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- Reinheit: 98.0%
- CAS. Nr.: 1534358-79-6
- Formel: C25H25NO5
- Molecular Weight:419.47
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) COH000
More
Biologische Aktivität
IC50: 0.2 μM (SUMO-activating enzyme)[1].
COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1534358-79-6
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Appearance Solid
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Molecular Weight 419.47
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Formel C25H25NO5
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Color Light yellow to yellow
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SMILES
CC(C=C1)=CC=C1C[C@@H](NC2=CC=CC=C2)[C@]34C(C(OC)=O)=C(C(OC)=O)[C@@H](O4)C=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Mol Med
SENP1 promotes p27kip1 nuclear export though enhanced SUMOylation in cholangiocarcinoma leading to increased cell proliferation and chemoresistance. [Abstract]2025 Sep;56(3):141. PMID: 40682835 -
Lösungsmittel & Löslichkeit
DMSO : 35.71 mg/mL (85.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (600 KB)
- English - EN (600 KB)
- Français - FR (600 KB)
- Deutsch - DE (600 KB)
- Norwegian - NO (600 KB)
- Español - ES (600 KB)
- Swedish - SV (600 KB)
- Italian - IT (600 KB)
- Korean - KR (600 KB)
- Portuguese - PT (600 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3840 mL | 11.9198 mL | 23.8396 mL | 59.5990 mL |
| 5 mM | 0.4768 mL | 2.3840 mL | 4.7679 mL | 11.9198 mL | |
| 10 mM | 0.2384 mL | 1.1920 mL | 2.3840 mL | 5.9599 mL | |
| 15 mM | 0.1589 mL | 0.7947 mL | 1.5893 mL | 3.9733 mL | |
| 20 mM | 0.1192 mL | 0.5960 mL | 1.1920 mL | 2.9800 mL | |
| 25 mM | 0.0954 mL | 0.4768 mL | 0.9536 mL | 2.3840 mL | |
| 30 mM | 0.0795 mL | 0.3973 mL | 0.7947 mL | 1.9866 mL | |
| 40 mM | 0.0596 mL | 0.2980 mL | 0.5960 mL | 1.4900 mL | |
| 50 mM | 0.0477 mL | 0.2384 mL | 0.4768 mL | 1.1920 mL | |
| 60 mM | 0.0397 mL | 0.1987 mL | 0.3973 mL | 0.9933 mL | |
| 80 mM | 0.0298 mL | 0.1490 mL | 0.2980 mL | 0.7450 mL |
COH000 Related Classifications
HY-114304 Related Classifications
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