Art. -Nr.: HY-B0972

Cinchophen

Name: Cinchophen
Brand: MedChemExpress
SKU: HY-B0972
Price: 25.00 USD
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1 Cited Publications

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Cinchophen is a potent and orally active non-steroidal anti-inflammatory agent, has analgesic and antimicrobial effects. Cinchophen can be used for the research of arthritis and some liver diseases.

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Reinheit: 99.97%
CAS. Nr.: 132-60-5
Formel: C₁₆H₁₁NO₂
Molecular Weight:249.27

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Cinchophen Chemical Structure

CAS. Nr.: 132-60-5

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>100 μM Compound: 10	Antiproliferative activity against human HCT116 cells over-expressing DHODH after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells over-expressing DHODH after 72 hrs by MTT assay	[PMID: 29727569]
MIA PaCa-2	IC₅₀	>100 μM Compound: 10	Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay	[PMID: 29727569]
Sf21	IC₅₀	295.8 μM Compound: Cinchophen	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	695.3 μM Compound: Cinchophen	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]

In Vivo

Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone^[2].
The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (V_d area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t_1/2β) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs^[2].
Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (C_max) of 77.75 μg/ml and the time of Cmax (t_max) is 2.76 hours. The plasma concentration time curve (AUC_0-∞) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 132-60-5
Appearance Solid
Molecular Weight 249.27
Formel C₁₆H₁₁NO₂
Color White to off-white
SMILES

O=C(C1=CC(C2=CC=CC=C2)=NC3=CC=CC=C13)O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Ecotoxicol Environ Saf

Cinchophen induces RPA1 related DNA damage and apoptosis to impair ENS development of zebrafish. [Abstract]

2024 Mar 1:272:116032. PMID: 38306819

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 83.33 mg/mL (334.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.0117 mL

20.0587 mL

40.1173 mL

5 mM

0.8023 mL

4.0117 mL

8.0235 mL

10 mM

0.4012 mL

2.0059 mL

4.0117 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (10.03 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (8.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (8.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. R.G. Snyder, M.D, et al. The use of cinchophen in the treatment of chronic arthritis. THE AMERICAN ASSOCIATION FOR THE STUDY AND CONTROL OF RHEUMATIC DISEASE

[2]. Q. A. McKellar, et al. Pharmacokinetics and clinical efficacy of a cinchophen and prednisolone combination in the dog. Jsap. Volume32, Issue2. February 1991

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.0117 mL	20.0587 mL	40.1173 mL	100.2933 mL
	5 mM	0.8023 mL	4.0117 mL	8.0235 mL	20.0587 mL
	10 mM	0.4012 mL	2.0059 mL	4.0117 mL	10.0293 mL
	15 mM	0.2674 mL	1.3372 mL	2.6745 mL	6.6862 mL
	20 mM	0.2006 mL	1.0029 mL	2.0059 mL	5.0147 mL
	25 mM	0.1605 mL	0.8023 mL	1.6047 mL	4.0117 mL
	30 mM	0.1337 mL	0.6686 mL	1.3372 mL	3.3431 mL
	40 mM	0.1003 mL	0.5015 mL	1.0029 mL	2.5073 mL
	50 mM	0.0802 mL	0.4012 mL	0.8023 mL	2.0059 mL
	60 mM	0.0669 mL	0.3343 mL	0.6686 mL	1.6716 mL
	80 mM	0.0501 mL	0.2507 mL	0.5015 mL	1.2537 mL
	100 mM	0.0401 mL	0.2006 mL	0.4012 mL	1.0029 mL

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Keywords

Cinchophen

1 Cited Publications

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Cinchophen

Cinchophen (Standard)

2,8-Quinolinediol

Nitrochin

Nitroxoline

BAY32-5915

Nitroxoline (Standard)

2,6-Dimethylquinoline

2-Hydroxyquinoline

4-Quinolinol

5-Hydroxyquinoline

8-Aminoquinoline

6-Methoxyquinoline

Publications Citing Use of MedChemExpress (MCE) Cinchophen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

Cinchophen

Cinchophen (Standard)

2,8-Quinolinediol

Nitrochin

Nitroxoline

BAY32-5915

Nitroxoline (Standard)

2,6-Dimethylquinoline

2-Hydroxyquinoline

4-Quinolinol

5-Hydroxyquinoline

8-Aminoquinoline

6-Methoxyquinoline

Publications Citing Use of MedChemExpress (MCE) Cinchophen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Cinchophen Related Classifications

HY-B0972 Related Classifications

Bioz