Art. -Nr.: HY-16968

SW033291

Name: SW033291
Brand: MedChemExpress
SKU: HY-16968
Price: 100.00 USD
Availability: InStock
Rating: 5 (8 reviews)

8 Cited Publications

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Based on 8 publication(s) in Google Scholar

SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a K_i of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration.

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Reinheit : 99.36%
CAS. Nr.: 459147-39-8
Formel: C₂₁H₂₀N₂OS₃
Molecular Weight:412.59

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

SW033291 Chemical Structure

CAS. Nr.: 459147-39-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Ki: 0.1 nM (15-PGDH)^[1]

In Vitro

Treating cells with SW033291 decreases cellular 15-PGDH enzyme activity by 85%. SW033291 inhibition of 15-PGDH was non-competitive versus PGE2 over concentrations up to 40 μM PGE2. Treatment of A549 cells with SW033291 increases PGE2 levels by 3.5-fold at 500 nM, with an EC₅₀ 50 at approximately 75 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SW033291 (10 mg/kg; intraperitoneal injection; twice daily; for 3 days; C57BL/6J mice) treatment for three consecutive days shows significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice^[1]
Dosage:

10 mg/kg
Administration:

Intraperitoneal injection; twice daily; for 3 days ( for 5 doses)
Result:

Showed significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells.

Chemical Information

CAS. Nr. 459147-39-8
Appearance Solid
Molecular Weight 412.59
Formel C₂₁H₂₀N₂OS₃
Color Light yellow to yellow
SMILES

NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (8)

All Cell Proliferation/Viability AssayCell Imaging/StainingRT-PCRWBIHC

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Journal Impact Factor

Adv Sci (Weinh)

2026 Jul 7:e20994. PMID: 42411403
Stem Cell Res Ther

Effects of SW033291 on the myogenesis of muscle-derived stem cells and muscle regeneration. [Abstract]

2020 Feb 21;11(1):76. PMID: 32085799

SW033291 purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2020 Feb 21;11(1):76. [Abstract]

Cell viability of MDSCs in GM under different concentration of SW033291 (20, 50, 100, 500, 1000 nM) treatment.

SW033291 purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2020 Feb 21;11(1):76. [Abstract]

LIVE/DEAD staining of MDSCs cultured in DM and GM treated with different concentration of SW033291 (20, 50, 100, 500, 1000 nM) on day 1 and day 3.

SW033291 purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2020 Feb 21;11(1):76. [Abstract]

qPCR analysis of the expression of myogenic differentiation-related genes in MDSCs cultured in DM (top row) and GM (bottom row) under 100 nM SW033291 treatment on days 3 and 7.

SW033291 purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2020 Feb 21;11(1):76. [Abstract]

Western blot analysis of the protein expression of myogenic markers in MDSCs cultured in DM and GM under 100 nM SW033291 treatment on day 3.

SW033291 purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2020 Feb 21;11(1):76. [Abstract]

Cellular immunochemistry image of MHC in MDSCs cultured in DM and GM under 100 nM SW033291 treatment on day 7.
J Invest Dermatol

Activin A Sustains the Metastatic Phenotype of Tumor-Associated Macrophages and Is a Prognostic Marker in Human Cutaneous Melanoma. [Abstract]

2022 Mar;142(3 Pt A):653-661.e2. PMID: 34499901
Int Immunopharmacol

Adoptive transfer of TregIL-33 cells ameliorates acute graft-versus-host disease by regulating the HPGD/PGE2 pathway. [Abstract]

2026 Jan 1;168(Pt 1):115700. PMID: 41187423
Int J Mol Sci

The Enzyme 15-Hydroxyprostaglandin Dehydrogenase Inhibits a Shift to the Mesenchymal Pattern of Trophoblasts and Decidual Stromal Cells Accompanied by Prostaglandin Transporter in Preeclampsia. [Abstract]

2023 Mar 7;24(6):5111. PMID: 36982197
Bioorg Chem

15-Hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates hepatic abnormal lipid metabolism, ER stress, and inflammation through PGE2/EP4 in T2DM mice. [Abstract]

2023 Aug:137:106646. PMID: 37285764
Cell Signal

The 15-hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates abnormal hepatic glucose metabolism through PGE2-EP4 receptor-AKT signaling in a type 2 diabetes mellitus mouse model. [Abstract]

2023 Aug:108:110707. PMID: 37164143
J Biochem

Identification and characterization of bioactive metabolites of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. [Abstract]

2023 Mar 31;173(4):293-305. PMID: 36539331

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 33.33 mg/mL (80.78 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 25 mg/mL (60.59 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4237 mL

12.1186 mL

24.2371 mL

5 mM

0.4847 mL

2.4237 mL

4.8474 mL

10 mM

0.2424 mL

1.2119 mL

2.4237 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (6.06 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (6.06 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (6.06 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 4

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang Y, et al. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science. 2015 Jun 12;348(6240):aaa2340. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	2.4237 mL	12.1186 mL	24.2371 mL	60.5928 mL
	5 mM	0.4847 mL	2.4237 mL	4.8474 mL	12.1186 mL
	10 mM	0.2424 mL	1.2119 mL	2.4237 mL	6.0593 mL
	15 mM	0.1616 mL	0.8079 mL	1.6158 mL	4.0395 mL
	20 mM	0.1212 mL	0.6059 mL	1.2119 mL	3.0296 mL
	25 mM	0.0969 mL	0.4847 mL	0.9695 mL	2.4237 mL
	30 mM	0.0808 mL	0.4040 mL	0.8079 mL	2.0198 mL
	40 mM	0.0606 mL	0.3030 mL	0.6059 mL	1.5148 mL
	50 mM	0.0485 mL	0.2424 mL	0.4847 mL	1.2119 mL
	60 mM	0.0404 mL	0.2020 mL	0.4040 mL	1.0099 mL
DMSO	80 mM	0.0303 mL	0.1515 mL	0.3030 mL	0.7574 mL

Bioz

Keywords

SW033291

8 Cited Publications

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SW033291

Publications Citing Use of MedChemExpress (MCE) SW033291