ANT2681
ANT2681 is a potent NDM inhibitor with a Ki value of 0.04 μM against NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1 and IMP-1 with Ki values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem (HY-13678) to inhibit infections caused by NDM-producing Enterobacteriaceae.
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- CAS. Nr.: 2270184-16-0
- Formel: C12H11F2N7O5S2
- Molecular Weight:435.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Chemical Information
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Biologische Aktivität
Chemical Information
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CAS. Nr. 2270184-16-0
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Molecular Weight 435.39
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Formel C12H11F2N7O5S2
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SMILES
O=C(C1=C(NS(=O)(C2=CC(F)=C(C(F)=C2)NC(NNC(N)=N)=O)=O)SC=N1)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Davies DT, et al. ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae. ACS Infect Dis. 2020 Sep 11;6(9):2419-2430. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ANT2681 Related Classifications
HY-176519 Related Classifications
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