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Apoptosis inducer 7

1 Cited Publications

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Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity.

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CAS. Nr.: 2252278-57-0
Formel: C₄₉H₆₈N₂O₇
Molecular Weight:797.07

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Apoptosis inducer 7 Chemical Structure

CAS. Nr.: 2252278-57-0

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- In Vitro
- In Vivo
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Publications (1)
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Biologische Aktivität

Beschreibung

In Vitro

Apoptosis inducer 7 (Compound 5I) (0.098-50 μM, 96 hours; human tumor cell lines) exerts the most potent antitumor activities against human cancer cell lines^[1].
Apoptosis inducer 7 (Compound 5I) induces apoptosis in HCT-116 cells, and the apoptosis induction is related to the downregulation of anti-apoptotic protein c-Flip and upregulation of pro-apoptotic protein Noxa^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Human breast cancer MDA-MB-231 cells, human lung cancer A549 cells, human colorectal cancer HCT-116 cells, human liver cancer HepG-2 cells and one non-tumor human breast epithelial MCF-10A cells.
Concentration:

0.098-50 μM
Incubation Time:

96 hours
Result:

Inhibited with IC₅₀ values of 0.22, 0.15, 0.42, 0.14 and 1.03 μM for MDA-MB-231, A549, HCT-116, HepG-2 and MCF-10A, respectively.

Cell Cycle Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

0.5, 0.75 and 1.0 μM
Incubation Time:

24 hours
Result:

More than 40% of the cells were detected in the sub G1 phase.

Western Blot Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

0.5, 0.75 and 1.0 μM
Incubation Time:

24 hours
Result:

Induced cleavage of PARP, caspases and decreased the levels of c-Flip and HDAC3 proteins.

In Vivo

Apoptosis inducer 7 (Compound 5I) (5 mg/kg; i.p.; three times a week, for 14 days; LL/2 xenograft model in C57/ BL6J mice) inhibits tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

KARPAS-422 subcutaneous xenograft in mice^[1]
Dosage:

5 mg/kg
Administration:

Intraperitoneal injection; three times a week, for 14 days.
Result:

Inhibited the tumor growth with an inhibition rate of 62.3%, without significant body weight loss.

Chemical Information

CAS. Nr. 2252278-57-0
Molecular Weight 797.07
Formel C₄₉H₆₈N₂O₇
SMILES

C[C@]12[C@@](C(C=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(OCC5=CC=CC=C5)=O)C)C)=O)([H])[C@@]6([C@@](C(C)(C(/C(C6)=C/C(NC7CCN(CC7)C(OC(C)(C)C)=O)=O)=O)C)([H])CC1)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Bone Res

The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer. [Abstract]

2024 Aug 27;12(1):47. PMID: 39191757

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Reinheit: 99.98%

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ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huang M, et al. Synthesis and antitumor effects of novel 18β-glycyrrhetinic acid derivatives featuring an exocyclic α,β-unsaturated carbonyl moiety in ring A. Bioorg Chem. 2020 Oct;103:104187. [Content Brief]

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Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Apoptosis inducer 7

1 Cited Publications

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Apoptosis inducer 7

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Art. -Nr.: HY-149017