Auristatin S
Auristatin S is a potent Auristatin payload. Auristatin S binds to the vinca-binding site on tubulin, thereby inhibiting microtubule assembly and inducing cell cycle arrest and apoptosis. Auristatin S acts as a cytotoxic component of antibody-drug conjugates (ADCs) and exerts target-specific cytotoxicity against cancer cells. Auristatin S can be used in the research of lymphoma, anaplastic large cell lymphoma and Hodgkin lymphoma.
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- CAS. Nr.: 3028453-70-2
- Formel: C38H65N5O8
- Molecular Weight:719.95
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
Auristatin S (1.4 μM; 1 h) competes with FITC-MMAE for binding to tubulin in a cell-free system[1].
Auristatin S has a LogD value of 1.6, exhibiting lower hydrophobicity and cell permeability compared with MMAE[1].
Auristatin S (96 h) exerts in vitro cytotoxic effects in lymphoma cell lines (DEL, Karpas299, KarpasBVR, L540cy, etc.), with a mean IC50 value of 20 nM[1].
Auristatin S (100 nM; 18-72 h) induces markers of immunogenic cell death (HMGB1 release and ATP release) in MiaPaCa and L540cy cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Flow cytometric DNA-content cell-cycle staining
- Cell Cytotoxicity Assay
- Mammalian live/dead viability and cytotoxicity staining
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Apoptosis Solutions
- Protocol for Cell Cycle
- Cell Viability Determination by MTT Colorimetric Assay
Chemical Information
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CAS. Nr. 3028453-70-2
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Molecular Weight 719.95
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Formel C38H65N5O8
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SMILES
CC[C@@H]([C@H](N(C([C@H](C(C)C)NC([C@H](CO)N(C)C)=O)=O)C)[C@H](OC)CC(N1CCC[C@H]1[C@@H]([C@@H](C)C(N[C@@H](CC2=CC=CC=C2)CO)=O)OC)=O)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Auristatin S Related Classifications
HY-164107 Related Classifications
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