BAY-9835
Based on 1 publication(s) in Google Scholar
BAY-9835, a chemical probe, is an orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. BAY-9835 exhibits inhibitory potencies vs mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the study of atherogenesis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.46%
- CAS. Nr.: 3032487-31-0
- Formel: C22H16F5N5O3
- Molecular Weight:493.39
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BAY-9835
More
Biologische Aktivität
IC50: 6 nM (ADAMTS7) and 30 nM (ADAMTS12)[1]
BAY-9835 (Compound 32) exhibits high metabolic stability in an incubation with human microsomes (Clbl = 10−4 L/h/kg) and no degradation observed over 24 h when stirring in human plasma[1].
BAY-9835 does not exhibit inhibition of CYP1A2, 2C8, 2C9, 2D6, and 3A4 enzymes (< 20 μM) and cardiac ion channels (hERG, hNav1.5, hCav1.2) (< 10 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | AUC | CL | Vss | T1/2 | Tmax | F |
|---|---|---|---|---|---|---|---|---|
| Dog[1] | 0.3 mg/kg | i.v. | 88 kg·h/L | 0.02 L/h/kg | 0.4 L/kg | 22 h | / | / |
| Dog[1] | 1 mg/kg | p.o. | 68 kg·h/L | / | / | 25 h | 5 h | 77 % |
| Mice[1] | 0.3 mg/kg | i.v. | 1.5 kg·h/L | 1.1 L/h/kg | 1.6 L/kg | 2.1 h | / | / |
| Mice[1] | 1 mg/kg | p.o. | 2.0 kg·h/L | / | / | 2.5 h | 1 h | 100 % |
| Rat[1] | 0.3 mg/kg | i.v. | 3.1 kg·h/L | 0.55 L/h/kg | 1.2 L/kg | 3.6 h | / | / |
| Rat[1] | 1 mg/kg | p.o. | 3.0 kg·h/L | / | / | 3.7 h | 2 h | 96 % |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3032487-31-0
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Appearance Solid
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Molecular Weight 493.39
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Formel C22H16F5N5O3
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Color White to off-white
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SMILES
O=C(C1=CC=C(F)C(F)=C1C2=CC=C(C(F)(F)F)C=C2)NC[C@@](C(N3)=O)(C4=CC=NN4C)NC3=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (202.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0268 mL | 10.1340 mL | 20.2679 mL | 50.6699 mL |
| 5 mM | 0.4054 mL | 2.0268 mL | 4.0536 mL | 10.1340 mL | |
| 10 mM | 0.2027 mL | 1.0134 mL | 2.0268 mL | 5.0670 mL | |
| 15 mM | 0.1351 mL | 0.6756 mL | 1.3512 mL | 3.3780 mL | |
| 20 mM | 0.1013 mL | 0.5067 mL | 1.0134 mL | 2.5335 mL | |
| 25 mM | 0.0811 mL | 0.4054 mL | 0.8107 mL | 2.0268 mL | |
| 30 mM | 0.0676 mL | 0.3378 mL | 0.6756 mL | 1.6890 mL | |
| 40 mM | 0.0507 mL | 0.2533 mL | 0.5067 mL | 1.2667 mL | |
| 50 mM | 0.0405 mL | 0.2027 mL | 0.4054 mL | 1.0134 mL | |
| 60 mM | 0.0338 mL | 0.1689 mL | 0.3378 mL | 0.8445 mL | |
| 80 mM | 0.0253 mL | 0.1267 mL | 0.2533 mL | 0.6334 mL | |
| 100 mM | 0.0203 mL | 0.1013 mL | 0.2027 mL | 0.5067 mL |
BAY-9835 Related Classifications
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