Art. -Nr.: HY-110188

BiP inducer X

7 Cited Publications

Kundenbewertung

Based on 7 publication(s) in Google Scholar

BiP inducer X, a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78, is an effective ER (endoplasmic reticulum) stress inhibitor. BiP inducer X preferentially induces BiP with slight inductions of GRP94, calreticulin, and C/EBP homologous protein. BiP inducer X protects neurons from ER stress.

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Reinheit: 99.62%
CAS. Nr.: 101714-41-4
Formel: C₉H₇NO₃S
Molecular Weight:209.22

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BiP inducer X Chemical Structure

CAS. Nr.: 101714-41-4

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein^[1].
The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway^[1].
BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BiP inducer X administration reduces the insults due to cerebral infarction^[1].
A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male adult ddY mice weighing 24-34 g (Japan SLC)^[1]
Dosage:

20 μg (2 μl)
Administration:

Intracerebroventricularly
Result:

Significantly increased the level of BiP protein 24 h after administration, confirming that administration of BIX induces BiP protein in vivo.

Chemical Information

CAS. Nr. 101714-41-4
Appearance Solid
Molecular Weight 209.22
Formel C₉H₇NO₃S
Color Brown to gray
SMILES

N#CSCC(C1=CC(O)=C(O)C=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (7)

All RT-PCRCell Imaging/StainingIFWB

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Journal Impact Factor

Adv Sci (Weinh)

Acetylation of the Mitochondrial Chaperone GRP75 Governs ER-Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance. [Abstract]

2025 Sep 26:e08991. PMID: 41001747
Cell Mol Life Sci

Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc. [Abstract]

2024 Jan 22;81(1):49. PMID: 38252317
iScience

Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish. [Abstract]

2023 Oct 13;26(11):108207. PMID: 37942006

BiP inducer X purchased from MedChemExpress. Usage Cited in: iScience. 2023 Oct 13;26(11):108207. [Abstract]

Relative mRNA expression of BAF60c and GRP78 after BiP inducer X (BiP) (1, 5, 10 μM) treatment for 4 h with different concentrations in macrophages.
Neurochem Int

The ER chaperone, BIP protects Microglia from ER stress-mediated Apoptosis in Hyperglycemia. [Abstract]

2023 Oct:169:105573. PMID: 37454816

BiP inducer X purchased from MedChemExpress. Usage Cited in: Neurochem Int. 2023 Oct:169:105573. [Abstract]

Representative bright field image of BIX (25 μM) treated cells.

BiP inducer X purchased from MedChemExpress. Usage Cited in: Neurochem Int. 2023 Oct:169:105573. [Abstract]

Immunocytochemistry analysis of BIP, Texas Red fluorescence conjugated secondary antibody was used to detect BIP and DAPI for nuclear staining in BIX (25 μM)-treated cells.
Aquaculture

2023 Jun 8, 739757.
Virol J

Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation. [Abstract]

2025 Nov 17;22(1):378. PMID: 41250234
Research Square Print

2023 Mar 6.

BiP inducer X purchased from MedChemExpress. Usage Cited in: Research Square Print. 2023 Mar 6.

BiP inducer X (BIX; 25 mM) significantly reduces the expression levels of pro-apoptotic marker proteins including Bax, Bad, cytochrome-C, and caspase-1 in microglia cells.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (238.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.7797 mL

23.8983 mL

47.7966 mL

5 mM

0.9559 mL

4.7797 mL

9.5593 mL

10 mM

0.4780 mL

2.3898 mL

4.7797 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (11.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kudo T, et al. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008;15(2):364-375. [Content Brief]

[2]. Yoo SA, et al. A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. J Exp Med. 2012;209(4):871-886. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.7797 mL	23.8983 mL	47.7966 mL	119.4914 mL
	5 mM	0.9559 mL	4.7797 mL	9.5593 mL	23.8983 mL
	10 mM	0.4780 mL	2.3898 mL	4.7797 mL	11.9491 mL
	15 mM	0.3186 mL	1.5932 mL	3.1864 mL	7.9661 mL
	20 mM	0.2390 mL	1.1949 mL	2.3898 mL	5.9746 mL
	25 mM	0.1912 mL	0.9559 mL	1.9119 mL	4.7797 mL
	30 mM	0.1593 mL	0.7966 mL	1.5932 mL	3.9830 mL
	40 mM	0.1195 mL	0.5975 mL	1.1949 mL	2.9873 mL
	50 mM	0.0956 mL	0.4780 mL	0.9559 mL	2.3898 mL
	60 mM	0.0797 mL	0.3983 mL	0.7966 mL	1.9915 mL
	80 mM	0.0597 mL	0.2987 mL	0.5975 mL	1.4936 mL
	100 mM	0.0478 mL	0.2390 mL	0.4780 mL	1.1949 mL

Keywords

BiP inducer X

7 Cited Publications

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BiP inducer X

Apoptosis Compound Library

Endoplasmic Reticulum Stress Compound Library

Highly Selective Inhibitors Library

Cell Death Library

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Bioactive Compound Library

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High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) BiP inducer X

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

BiP inducer X

Apoptosis Compound Library

Endoplasmic Reticulum Stress Compound Library

Highly Selective Inhibitors Library

Cell Death Library

Bioactive Compound Library Max

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) BiP inducer X

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

BiP inducer X Related Classifications

HY-110188 Related Classifications