Art. -Nr.: HY-118545

Butamirate

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Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 96.48%
CAS. Nr.: 18109-80-3
Formel: C₁₈H₂₉NO₃
Molecular Weight:307.43

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Butamirate Chemical Structure

CAS. Nr.: 18109-80-3

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle STAT Isoform-spezifische Produkte anzeigen :

In Vitro

Butamirate (0.01-10 μM; 7 days) could effectively suppress sphere formation and STAT3 activity^[2].
Butamirate effectively inhibits interactions of RRAD with pSTAT3^[2].
Butamirate shows decreased EGFR, STAT3, ERK and AKT phosphorylation in U87MG^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

U87MG, U87MG-TMZ-resistant (U87 TMZR), U87MG-Lapatinib-resistant (U87 LAPAR) and T98G (TMZ resistant) tumorspheres
Concentration:

0.01-10 μM
Incubation Time:

7 days
Result:

Effectively suppressed growth of glioblastoma cell lines, including U87MG-TMZR and U87MG-LAPAR.

In Vivo

Butamirate (2 mg/kg; intraperitoneal administration) suppresses tumor growth in a glioblastoma xenograft mouse model without significant adverse effects^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male BALB/c nude mice (6- to 8 week-old) were subcutaneously injected with U87MG cells^[2]
Dosage:

2 mg/kg
Administration:

i.p; once a day; for 36 days.
Result:

Inhibited tumor growth in a glioblastoma mouse xenograft model.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 18109-80-3
Appearance Liquid (Density: 1.007±0.06 g/cm³)
Molecular Weight 307.43
Formel C₁₈H₂₉NO₃
Color Yellow to orange
SMILES

O=C(C(C1=CC=CC=C1)CC)OCCOCCN(CC)CC
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (325.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2528 mL

16.2639 mL

32.5277 mL

5 mM

0.6506 mL

3.2528 mL

6.5055 mL

10 mM

0.3253 mL

1.6264 mL

3.2528 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Płusa T. et al. Butamirate citrate in control of cough in respiratory tract inflammation. Pol Merkur Lekarski. 2017 Aug 21;43(254):69-74. [Content Brief]

[2]. Lee SJ, et al. Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents. Sci Rep. 2021 May 12;11(1):10145. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2528 mL	16.2639 mL	32.5277 mL	81.3193 mL
	5 mM	0.6506 mL	3.2528 mL	6.5055 mL	16.2639 mL
	10 mM	0.3253 mL	1.6264 mL	3.2528 mL	8.1319 mL
	15 mM	0.2169 mL	1.0843 mL	2.1685 mL	5.4213 mL
	20 mM	0.1626 mL	0.8132 mL	1.6264 mL	4.0660 mL
	25 mM	0.1301 mL	0.6506 mL	1.3011 mL	3.2528 mL
	30 mM	0.1084 mL	0.5421 mL	1.0843 mL	2.7106 mL
	40 mM	0.0813 mL	0.4066 mL	0.8132 mL	2.0330 mL
	50 mM	0.0651 mL	0.3253 mL	0.6506 mL	1.6264 mL
	60 mM	0.0542 mL	0.2711 mL	0.5421 mL	1.3553 mL
	80 mM	0.0407 mL	0.2033 mL	0.4066 mL	1.0165 mL
	100 mM	0.0325 mL	0.1626 mL	0.3253 mL	0.8132 mL

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Butamirate

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

CNS-Penetrant Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Orally Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Cancer Stem Cells Compound Library

Anti-Drug-Resistant Compound Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Alle STAT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Butamirate

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

CNS-Penetrant Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Orally Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Cancer Stem Cells Compound Library

Anti-Drug-Resistant Compound Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Alle STAT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Butamirate Related Classifications

HY-118545 Related Classifications