C3361
C3361 is a moderate specific Plasmodium falciparum hexose transporter 1 (PfHT1) and Plasmodium berghei hexose transporter 1 (PbHT1) inhibitor with Ki values of 8.6 and 9.4 μM. C3361 inhibits TgGT1 with a Ki of 82 μM. C3361 attenuates hepatic (IC50 = 15 μM) and ookinete development of P. berghei. C3361 can suppress the growth of blood-stage parasites. C3361 can be used for the research of infection, such as malaria.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 91042-00-1
- Formel: C17H32O6
- Molecular Weight:332.43
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Parasite Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
C3361 reduces 75% ookinete formation[1].
C3361 (1-100 μM, 68 h) prevent the maturation of the liver-stage schizonts in sporozoite-infected hepatoma cells[1].
C3361 shows growth inhibition of P. berghei with an IC50 of 15 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Sporozoite-infected hepatoma cells
-
Concentration:1, 10, 50 and 100 μM
-
Incubation Time:68 h
-
Result:Decreased area of the liver schizonts.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:GFP-expressing parasite-infected blood cells infected mice models[1]
-
Dosage:2 mg/kg
-
Administration:Intraperitoneally injection, daily
-
Result:Reduced 45% parasitemia from days 3-5.
Chemical Information
-
CAS. Nr. 91042-00-1
-
Molecular Weight 332.43
-
Formel C17H32O6
-
SMILES
C=CCCCCCCCCCO[C@H]1[C@@H]([C@H](OC([C@@H]1O)O)CO)O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Huang J, et al. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2017749118. [Content Brief]
[2]. Blume M, et al. A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs. FASEB J. 2011 Apr;25(4):1218-29. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
C3361 Related Classifications
HY-17656 Related Classifications
Powered by Bioz