CAY10581
CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1018340-07-2
- Formel: C22H21NO4
- Molecular Weight:363.41
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
IDO 55 nM (IC50) |
CAY10581 (100 nM; 24 h) abrogates the growth inhibition by IFN-gamma in MSCs[1].
CAY10581 (compound 36) demonstrates minimal impact on T-REx cells viability at 100 μM after 24 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Mesenchymal stem cells (MSCs)
-
Concentration:100 nM
-
Incubation Time:24 h post-treatment
-
Result:Abrogated the growth inhibition by IFN-gamma (50 ng/ml) in MSCs.
Chemical Information
-
CAS. Nr. 1018340-07-2
-
Molecular Weight 363.41
-
Formel C22H21NO4
-
SMILES
O=C1C2=C(C(C3=C1C=CC=C3)=O)[C@@H]([C@@H](C(C)(O2)C)O)NCC4=CC=CC=C4
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Sanjeev Kumar, et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. [Content Brief]
[2]. Siddaraju V Boregowda, et al. A Clinical Indications Prediction Scale Based on TWIST1 for Human Mesenchymal Stem Cells. EBioMedicine. 2015 Dec 24;4:62-73. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CAY10581 Related Classifications
HY-113568 Related Classifications
Powered by Bioz