Art. -Nr.: HY-146185

CCT373566

Kundenbewertung

Based on 1 Customer Validation

CCT373566 is a potent and orally active molecular glue degrader of transcriptional repressor BCL6, with an IC₅₀ of 2.2 nM. CCT373566 shows strong antiproliferative efficacy in vitro and reduction in tumor growth in vivo.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.61%
CAS. Nr.: 2378853-66-6
Formel: C₂₆H₂₉ClF₂N₆O₃
Molecular Weight:547.00

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

CCT373566 Chemical Structure

CAS. Nr.: 2378853-66-6

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HT	GI₅₀	8 nM Compound: 12a; CCT373566	Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human HT cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]
KARPAS-422	GI₅₀	1.4 nM Compound: 12a; CCT373566	Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]
OCI-Ly1	GI₅₀	2.1 nM Compound: 12a; CCT373566	Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]
OCI-Ly3	GI₅₀	1900 nM Compound: 12a; CCT373566	Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]
SUD4	GI₅₀	12.5 nM Compound: 12a; CCT373566	Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay Antiproliferative activity against human SU-DHL-4 cells assessed as cell growth inhibition incubated for 14 days by Cell Titer Glo assay	[PMID: 35653645]

Chemical Information

CAS. Nr. 2378853-66-6
Appearance Solid
Molecular Weight 547.00
Formel C₂₆H₂₉ClF₂N₆O₃
Color Light yellow to yellow
SMILES

O=C1N(C)C2=C(C=C(NC3=NC(N4C[C@H](O)C[C@H](C)C4)=NC=C3Cl)C=C2)C5=C1OCC(F)(F)[C@H](C6CC6)N5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (91.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8282 mL

9.1408 mL

18.2815 mL

5 mM

0.3656 mL

1.8282 mL

3.6563 mL

10 mM

0.1828 mL

0.9141 mL

1.8282 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huckvale R, et, al. Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo. J Med Chem. 2022 Jun 23;65(12):8191-8207. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8282 mL	9.1408 mL	18.2815 mL	45.7038 mL
	5 mM	0.3656 mL	1.8282 mL	3.6563 mL	9.1408 mL
	10 mM	0.1828 mL	0.9141 mL	1.8282 mL	4.5704 mL
	15 mM	0.1219 mL	0.6094 mL	1.2188 mL	3.0469 mL
	20 mM	0.0914 mL	0.4570 mL	0.9141 mL	2.2852 mL
	25 mM	0.0731 mL	0.3656 mL	0.7313 mL	1.8282 mL
	30 mM	0.0609 mL	0.3047 mL	0.6094 mL	1.5235 mL
	40 mM	0.0457 mL	0.2285 mL	0.4570 mL	1.1426 mL
	50 mM	0.0366 mL	0.1828 mL	0.3656 mL	0.9141 mL
	60 mM	0.0305 mL	0.1523 mL	0.3047 mL	0.7617 mL
	80 mM	0.0229 mL	0.1143 mL	0.2285 mL	0.5713 mL

Keywords

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

CCT373566

MCE Bioactive Compound Library

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CCT373566 Related Classifications

HY-146185 Related Classifications