CFTR corrector 8
Based on 1 Customer Validation
CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 95.86%
- CAS. Nr.: 1918142-35-4
- Formel: C29H27F2NO7
- Molecular Weight:539.52
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Biologische Aktivität
Chemical Information
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CAS. Nr. 1918142-35-4
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Appearance Solid
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Molecular Weight 539.52
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Formel C29H27F2NO7
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Color Off-white to pink
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SMILES
COC(C=C1[C@H](C2)OC3=CC(OC)=CC=C3[C@H]2NC(C4(C5=CC=C(OC(F)(O6)F)C6=C5)CC4)=O)=C(C=C1)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 110 mg/mL (203.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61(4):1436-1449. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8535 mL | 9.2675 mL | 18.5350 mL | 46.3375 mL |
| 5 mM | 0.3707 mL | 1.8535 mL | 3.7070 mL | 9.2675 mL | |
| 10 mM | 0.1853 mL | 0.9267 mL | 1.8535 mL | 4.6337 mL | |
| 15 mM | 0.1236 mL | 0.6178 mL | 1.2357 mL | 3.0892 mL | |
| 20 mM | 0.0927 mL | 0.4634 mL | 0.9267 mL | 2.3169 mL | |
| 25 mM | 0.0741 mL | 0.3707 mL | 0.7414 mL | 1.8535 mL | |
| 30 mM | 0.0618 mL | 0.3089 mL | 0.6178 mL | 1.5446 mL | |
| 40 mM | 0.0463 mL | 0.2317 mL | 0.4634 mL | 1.1584 mL | |
| 50 mM | 0.0371 mL | 0.1853 mL | 0.3707 mL | 0.9267 mL | |
| 60 mM | 0.0309 mL | 0.1545 mL | 0.3089 mL | 0.7723 mL | |
| 80 mM | 0.0232 mL | 0.1158 mL | 0.2317 mL | 0.5792 mL | |
| 100 mM | 0.0185 mL | 0.0927 mL | 0.1853 mL | 0.4634 mL |
CFTR corrector 8 Related Classifications
HY-147249 Related Classifications
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