CPF-7
CPF-7 (Caerulein precursor fragment) is an insulin-releasing peptide that stimulates the release of insulin. CPF-7 can induce epithelial-mesenchymal transition by upregulating Snai1 expression in PANC-1 ductal cells. CPF-7 also induces exocrine plasticity by upregulating Ngn3 expression. CPF-7 can be used in the research of type 2 diabetes.
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- CAS. Nr.: 103238-06-8
- Formel: C118H193N33O32
- Molecular Weight:2586.00
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
CPF-7 (50 nM; 7 days) converts PANC-1 exocrine cells into pancreatic endocrine precursor cells[1].
CPF-7 (3 µM; 20 min) produces the stimulation of insulin release in BRIN-BD11 rat clonal β-cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PANC1 cells
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Concentration:50 nM
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Incubation Time:7 days (change medium every 24 h)
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Result:Increased Ngn3 (the principal determinant of endocrine precursor cells) expression level.
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Cell Line:BRIN-BD11 rat clonal β-cells
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Concentration:3 µM
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Incubation Time:20 min
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Result:Stimulated insulin release.
Chemical Information
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CAS. Nr. 103238-06-8
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Molecular Weight 2586.00
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Formel C118H193N33O32
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Synonyms
Caerulein precursor fragment
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Sequence
Gly-Phe-Gly-Ser-Phe-Leu-Gly-Lys-Ala-Leu-Lys-Ala-Ala-Leu-Lys-Ile-Gly-Ala-Asn-Ala-Leu-Gly-Gly-Ala-Pro-Gln-Gln
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Sequence Shortening
GFGSFLGKALKAALKIGANALGGAPQQ
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Heydari M, et al. Differentiation of PANC-1 ductal cells to β-like cells via cellular GABA modulation by Magainin and CPF-7 peptides. Biochem Biophys Res Commun. 2022 Feb 1;597:128-133. [Content Brief]
[2]. Srinivasan D, et al. Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents. Biochimie. 2013 Feb;95(2):429-35. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CPF-7 Related Classifications
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