DC07090
DC07090 is a potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM.
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- CAS. Nr.: 879070-72-1
- Formel: C18H14N4O
- Molecular Weight:302.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: 21.72 μM (EV71 3C protease)[1].
Ki: 23.29 μM (EV71 3C protease)[1].
EC50: 27.76 μM (coxsackievirus A16)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RD | CC50 |
>200 μM
Compound: DC07090
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Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay
Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay
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[PMID: 27776325] |
DC07090 forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 inhibits CVA16 with an EC50 value of 27.76 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 879070-72-1
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Molecular Weight 302.33
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Formel C18H14N4O
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SMILES
C1(C(C=C2)=CC=C2NCC3=NC=CC=C3)=NC(N=CC=C4)=C4O1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DC07090 Related Classifications
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