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Art. -Nr.: HY-N13756

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Deoxymikanolide

Deoxymikanolide is an orally active antibacterial agent that inhibits catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. Deoxymikanolide increases glycan metabolism, phosphorus metabolism, electric conductivity, intrabacterial reactive oxygen species (ROS) levels, and malondialdehyde (MDA) levels, causes cell shrinkage, cytoplasmic damage, and cell disruption in Ralstonia solanacearum. Deoxymikanolide inhibits Acetic acid-induced writhing in mice. Deoxymikanolide can be used for the research of bacterial wilt.

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CAS. Nr.: 23753-57-3
Formel: C₁₅H₁₆O₅
Molecular Weight:276.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Deoxymikanolide Chemical Structure

CAS. Nr.: 23753-57-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Deoxymikanolide (15.625-125 mg/L; measured at 2-hour intervals) inhibits the growth of Ralstonia solanacearum race #4 in a concentration-dependent manner, with complete suppression at higher concentrations^[1].
Deoxymikanolide (125 mg/L; 2-24 h) induces time-dependent ultrastructural damage to Ralstonia solanacearum race #4, including cell shrinkage, cytoplasmic leakage, and abnormal cell shapes, with complete cytoderm thickening at 24 h^[1].
Deoxymikanolide (62.5-125 mg/L; measured every 2 h for 24 h) significantly increases the phosphorus utilization ratio of Ralstonia solanacearum race #4^[1].
Deoxymikanolide (62.5-125 mg/L; measured at 5-hour intervals) inhibits the activities of CAT, POD, and SOD in Ralstonia solanacearum race #4, with SOD inhibition rates of 73.50% (62.5 mg/l) and 86.41% (125 mg/L) at 10 min^[1].
Deoxymikanolide (62.5-125 mg/L; 24 h) induces significant intracellular ROS accumulation in Ralstonia solanacearum race #4, exceeding levels induced by 340 mg/l H₂O₂^[1].
Deoxymikanolide (62.5-125 mg/L; 24 h post-treatment) increases MDA levels in Ralstonia solanacearum race #4 at 24 h, indicating lipid peroxidation from excessive ROS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Deoxymikanolide (10 mg/kg; p.o.) inhibits Acetic acid (HY-Y0319)-induced writhing in male Swiss mice (20-25 g) pain model (with an inhibition rate of 67.3%)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice (male, 20-25 g)^[2]
Dosage:

10 mg/kg
Administration:

p.o.
Result:

Reduced acetic acid-induced writhing to 8.5 and produced a 67.3% inhibition of writhing compared to the control group (26.0 writhings).

Chemical Information

CAS. Nr. 23753-57-3
Molecular Weight 276.28
Formel C₁₅H₁₆O₅
SMILES

C=C1[C@]2([H])[C@](OC1=O)([H])C[C@]3([C@@](CCC4=C[C@@]2([H])OC4=O)([H])O3)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li Y, et al. Deoxymikanolide adversely altered physiology and ultrastructure of Ralstonia solanacearum. Pestic Biochem Physiol. 2021;174:104803. [Content Brief]

[2]. Ahmed M, et al. Analgesic sesquiterpene dilactone from Mikania cordata. Fitoterapia. 2001;72(8):919-921. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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