Dirozalkib
Dirozalkib is an orally active and blood-brain barrier-penetrant ALK tyrosine kinase inhibitor. Dirozalkib inhibits the proliferation of ALK fusion-positive and ALK TKI-resistant tumor cells, and inhibits tumor growth in PDX and intracranial xenograft lung cancer models. Dirozalkib can be used for research related to non-small cell lung cancer.
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- CAS. Nr.: 1893419-37-8
- Formel: C27H32ClN5O4S
- Molecular Weight:558.09
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Dirozalkib (50 mg/kg; p.o.; once daily; for 21 consecutive days) produces potent tumor growth inhibition in the LU-01-0414 non-small cell lung cancer PDX model[1].
Dirozalkib (100 mg/kg; p.o.; once daily; 14 days) inhibits intracranial tumor growth and prolongs survival in the H2228-luc non-small cell lung cancer xenograft model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Patient-Derived Xenograft (PDX)
- Patient-Derived Orthotopic Xenograft (PDOX)
- Brain Orthotopic Xenograft
- Splenic/Portal-Vein Liver Metastasis Xenograft
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Cell Viability Determination by MTT Colorimetric Assay
- Intraperitoneal/Peritoneal Dissemination Xenograft
Chemical Information
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CAS. Nr. 1893419-37-8
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Molecular Weight 558.09
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Formel C27H32ClN5O4S
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SMILES
O=S(C1=C(NC2=NC(NC3=C4OCCOC4=C(C5CCNCC5)C(C)=C3)=NC=C2Cl)C=CC=C1)(C(C)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Dirozalkib Related Classifications
HY-172426 Related Classifications
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Keywords
- Dirozalkib
- 1893419-37-8
- Anaplastic lymphoma kinase (ALK)
- ALK TKI-resistant tumor cells
- ALK fusion-positive tumor cells
- ALK resistance mutations
- ALK tyrosine kinase
- ATP site
- STAT3 signaling
- autophosphorylation
- blood-brain barrier penetration
- intracranial xenograft
- non-small cell lung cancer
- Inhibitor
- inhibitor
- inhibit