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Art. -Nr.: HY-179334

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DMA-155

DMA-155 is an antiviral agent with binding activity against SARS-CoV-2 5'-terminal stem-loop RNAs, with affinities of 51.1 μM (SL1), 61.1 μM (SL4), 54.5 μM (SL5a), 66.9 μM (SL5b) and 48.6 μM (SL6), respectively. DMA-155 inhibits SARS-CoV-2 viral replication and reduces SARS-CoV-2 viral RNA levels. DMA-155 is applicable to the research of COVID-19.

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CAS. Nr.: 2237925-69-6
Formel: C₂₀H₂₁N₇O
Molecular Weight:375.43

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Please store the product under the recommended conditions in the Certificate of Analysis.

DMA-155 Chemical Structure

CAS. Nr.: 2237925-69-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

DMA-155 (50-100 μM; 24 h) significantly inhibits human coronavirus OC43 replication in Vero E6 cells when administered at 50 μM or 100 μM for 24 hours^[1].
DMA-155 (24-72 h) potently inhibits SARS-CoV-2 replication in Vero E6 cells with an IC₅₀ of 16 μM at 24 hours post-infection, with sustained dose-dependent activity through 72 hours^[1].
DMA-155 (10 μM; 72 h) inhibits SARS-CoV-2 replication in Vero E6 cells at 10 μM for 72 hours without significant cellular toxicity^[1].
DMA-155 (0.1-100 μM; 2 days) specifically inhibits SARS-CoV-2 5'-UTR-dependent translation in Vero E6 cells, with a ~90% reduction in FLuc activity at 10 μM after 2 days of incubation, without non-specific effects on translation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2237925-69-6
Molecular Weight 375.43
Formel C₂₀H₂₁N₇O
SMILES

O=C(C1=C(N)N=C(N(C)C)C(C2=CC=C(C3=CC=CC=C3)C=C2)=N1)NC(N)=N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Amanda HARGROVE, et al. Amiloride derivatives and methods of using same for the treatment of viral infections. WO2022120150A1.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DMA-155

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

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DMA-155 Related Classifications

HY-179334 Related Classifications