EIDD-1723
EIDD-1723 is a Progesterone (HY-N0437) analogues, that binds progesterone receptor (PR) with an IC50 of 2.25 μM. EIDD-1723 is the prodrug of EIDD-036 (HY-17649). EIDD-1723 may exert its neuroprotective effects not solely through progesterone receptor (PR)-dependent pathways but also via non-genomic mechanisms, such as modulation of inflammatory responses and oxidative stress. EIDD-1723 can be used for the study of traumatic brain injury (TBI).
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- CAS. Nr.: 1659302-89-2
- Formel: C22H32NNa2O6P
- Molecular Weight:483.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
EIDD-1723 (10 mg/kg, i.m., for 9 doses) significantly reduces cerebral edema and improved recovery from motor, sensory and spatial learning deficits in rats[1][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:
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Dosage:10 mg/kg
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Administration:Intramuscular injection (i.m.), at 1, 6, and 24 h and 2, 3, 4, 5, 6, and 7 days post-injury
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Result:Significantly reduced cerebral edema, improved motor function, shortened the delay time of sensory neglect, and enhanced spatial learning ability.
Significantly reduced brain tissue damage and weakened the activation of astrocytes and microglia cells.
Chemical Information
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CAS. Nr. 1659302-89-2
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Molecular Weight 483.45
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Formel C22H32NNa2O6P
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SMILES
C[C@@]12[C@](CC[C@@H]2/C(C)=N/OCOP(O[Na])(O[Na])=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=CC(CC4)=O)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Wali B, et al. Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats. Neuropharmacology. 2016 Oct;109:148-158. [Content Brief]
[2]. Fritzemeier RG, et al. Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury. J Med Chem. 2023 Apr 27;66(8):5397-5414. [Content Brief]
[3]. Sayeed I, et al. Development of a novel progesterone analog in the treatment of traumatic brain injury. Neuropharmacology. 2019 Feb;145(Pt B):292-298. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
EIDD-1723 Related Classifications
HY-125547 Related Classifications
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