Fulranumab
Based on 1 Customer Validation
Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 96.74%
- CAS. Nr.: 902141-80-4
- Molecular Weight:145.37 kDa
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Speicherung:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
Isotype
Human IgG2 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
NGF/bNGF
In Vitro
Fulranumab (200 μg/mL; 60 min) completely inhibits 10 ng/mL anti-fulranumab monkey polyclonal antibody, inhibits 100 and 1,000 ng/mL of anti-fulranumab antibody by over 90%[1].
Fulranumab (5-100 μg/mL) partially and dose dependently suppresses the false-positive anti-drug antibody (ADA) caused by acid pretreatment NGF[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG2 kappa
Anwendung
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1.5×106SHSY5Y cells labeling Fulranumab (HY-P99200, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa Isotype Control (HY-P99002, blue) was used as the isotype control.
Chemical Information
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CAS. Nr. 902141-80-4
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Appearance Liquid
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Molecular Weight 145.37 kDa
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Color Colorless to light yellow
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SMILES
[Fulranumab]
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Versand
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)