Blm - BLM RecQ like helicase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 308755

Summary

Predicted to enable several functions, including ATP binding activity; DNA binding activity; and DNA helicase activity. Predicted to be involved in several processes, including DNA geometric change; DNA metabolic process; and regulation of cellular macromolecule biosynthetic process. Predicted to act upstream of or within several processes, including negative regulation of thymocyte apoptotic process; regulation of DNA recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in cytosol; nucleus; and replication fork. Predicted to be part of protein-containing complex. Predicted to be active in chromosome; cytoplasm; and nucleus. Predicted to colocalize with PML body and chromosome, telomeric region. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]

Blm Products (4)

mRNA Protein Name
XM_039101057.1 XP_038956985.1 Bloom syndrome protein isoform X2
XM_039101056.1 XP_038956984.1 Bloom syndrome protein isoform X1
XM_003748888.5 XP_003748936.2 Bloom syndrome protein isoform X4
XM_006229458.4 XP_006229520.1 Bloom syndrome protein isoform X3
Protein Preferred Names Protein Names

BLM RecQ like helicase

Bloom syndrome protein

  • Bloom syndrome RecQ like helicase

  • Bloom syndrome homolog

  • Bloom syndrome, RecQ helicase-like

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-P3239 Belantamab mafodotin 99.78% Unkown

Pre-clinical Phase

Bioactive Molecules (17)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-12342 ML216 Inhibitor 99.89% Unkown
HY-110185 NSC 617145 Inhibitor 99.53% Unkown
HY-111756 BLM-IN-1 Inducer 98.04% Unkown
HY-128712 NCGC00029283 Inhibitor 98.88% Unkown
HY-151939 BLM-IN-2 Inducer / Unkown
HY-173483 ATX inhibitor 26 Inhibitor / Unkown
HY-175033 BRD4-IN-11 Inhibitor / Unkown
HY-175277 PIM1-IN-8 Inhibitor / Unkown
HY-176194 Antifibrotic agent 1 / Unkown
HY-178991 WRN-IN-21 Inhibitor / Unkown
HY-179645 Phosphodiesterase-IN-5 / Unkown
HY-181850 Telomeric G4s ligand 2 / Unkown
HY-182634 NCGC00063279 Inhibitor / Unkown
HY-183610 WRN-IN-26 / Unkown
HY-RS01520 BLM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16604 Blm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23038 Blm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Blm NCBI NCBI:641
Mus musculus Blm NCBI NCBI:12144