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MOB1A - MOB kinase activator 1A Gene

Also Known as MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MABKL1B; MOBKL1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55233

About MOB1A

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,152,528-74,178,879 (from NCBI)

This gene has 6 transcripts (splice variants), 122 orthologues and 6 paralogues. Ubiquitous expression in lymph node (RPKM 51.6), appendix (RPKM 43.0) and 24 other tissues.

Summary

The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing Apoptosis. Loss of the encoded protein results in cell proliferation and Cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

MOB1A Products (4)

mRNA	Protein	Name
NM_001317110.2	NP_001304039.1	MOB kinase activator 1A isoform 2
NM_001317111.2	NP_001304040.1	MOB kinase activator 1A isoform 3
NM_001317112.2	NP_001304041.1	MOB kinase activator 1A isoform 4
NM_018221.5	NP_060691.2	MOB kinase activator 1A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15197186	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	18328708	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	18328708	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	18328708	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOB1A Protein Structure

Mob1_phocein

0
100
200
216 a.a.

Protein Preferred Names	Protein Names
MOB kinase activator 1A	MOB1 Mps One Binder homolog A

MOB1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MOB1A	Q9H8S9	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	MOB1A	Q9H8S9	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	MOB1A	Q9H8S9	TMEM190	Homo sapiens	Q8WZ59	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	TMEM190	Homo sapiens	Q8WZ59	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	IKZF4	Homo sapiens	Q9H2S9	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	IKZF4	Homo sapiens	Q9H2S9	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	25416956
Intra	MOB1A	Q9H8S9	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	PCYT1A	Homo sapiens	P49585	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	PCYT1A	Homo sapiens	P49585	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	LZTFL1	Homo sapiens	Q9NQ48	Validated Y2H	32296183
Intra	MOB1A	Q9H8S9	LZTFL1	Homo sapiens	Q9NQ48	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	LZTFL1	Homo sapiens	Q9NQ48	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	LATS2	Homo sapiens	Q9NRM7	BioID	24255178
Intra	MOB1A	Q9H8S9	LATS2	Homo sapiens	Q9NRM7	Pull Down	19739119
Intra	MOB1A	Q9H8S9	LATS2	Homo sapiens	Q9NRM7	Anti Tag CoIP	24255178
Intra	MOB1A	Q9H8S9	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24255178
Intra	MOB1A	Q9H8S9	STK4	Homo sapiens	Q13043	BioID	24255178
Intra	MOB1A	Q9H8S9	STK4	Homo sapiens	Q13043	Y2H	23386615
Cross	MOB1A	Q9H8S9	q5zu83_legph	Legionella pneumophila subsp. pneumophila	Q5ZU83	Enzymatic Study	30212651
Intra	MOB1A	Q9H8S9	LATS1	Homo sapiens	O95835	BioID	24255178
Intra	MOB1A	Q9H8S9	LATS1	Homo sapiens	O95835	Anti Tag CoIP	24255178
Intra	MOB1A	Q9H8S9	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	MOB1A	Q9H8S9	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	CMTM3	Homo sapiens	Q96MX0	Validated Y2H	25416956
Intra	MOB1A	Q9H8S9	SEPTIN3	Homo sapiens	Q9UH03	Validated Y2H	32296183
Intra	MOB1A	Q9H8S9	SEPTIN3	Homo sapiens	Q9UH03	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	SEPTIN3	Homo sapiens	Q9UH03	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	KXD1	Homo sapiens	Q9BQD3	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	KXD1	Homo sapiens	Q9BQD3	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	TRIM32	Homo sapiens	Q13049	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	TRIM32	Homo sapiens	Q13049	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	TDO2	Homo sapiens	P48775	Validated Y2H	25416956
Intra	MOB1A	Q9H8S9	TDO2	Homo sapiens	P48775	Y2H Array	25416956
Intra	MOB1A	Q9H8S9	TDO2	Homo sapiens	P48775	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	TDO2	Homo sapiens	P48775	Y2H Prey Pooling	25416956
Intra	MOB1A	Q9H8S9	TDO2	Homo sapiens	P48775	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	FAM118A	Homo sapiens	Q9NWS6	Validated Y2H	25416956
Intra	MOB1A	Q9H8S9	FAM118A	Homo sapiens	Q9NWS6	Y2H Array	25416956
Intra	MOB1A	Q9H8S9	FAM118A	Homo sapiens	Q9NWS6	Y2H Prey Pooling	25416956
Intra	MOB1A	Q9H8S9	GMEB2	Homo sapiens	Q9UKD1	Validated Y2H	32296183
Intra	MOB1A	Q9H8S9	GMEB2	Homo sapiens	Q9UKD1	Y2H Array	32296183
Intra	MOB1A	Q9H8S9	GMEB2	Homo sapiens	Q9UKD1	Y2H Prey Pooling	32296183
Intra	MOB1A	Q9H8S9	STK38L	Homo sapiens	Q9Y2H1	BioID	24255178
Intra	MOB1A	Q9H8S9	STK38L	Homo sapiens	Q9Y2H1	Pull Down	15197186
Intra	MOB1A	Q9H8S9	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24255178
Intra	MOB1A	Q9H8S9	STK3	Homo sapiens	Q13188	BioID	24255178
Cross	MOB1A	Q9H8S9	Q9WMX2-PRO_0000037551	Hepatitis C virus	Q9WMX2-PRO_0000037551	Pull Down	18985028

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MOB1A Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70917	MOB1A Protein, Human (His)	Q9H8S9-1 (S2-R216)	≥ 95%, as determined by reducing SDS-PAGE.

MOB1A Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P86314	MOB1 Antibody (YA6006)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS08573	MOB1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21652	Mob1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28170	Mob1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MOB1A	RGD	RGD:1307014
Felis catus	MOB1A	VGNC	VGNC:63543
Bos taurus	MOB1A	VGNC	VGNC:31541
Mus musculus	MOB1A	MGD	MGI:2442631
Canis familiaris	MOB1A	VGNC	VGNC:43299
Others	MOB1A	NCBI