CRLF2 - cytokine receptor like factor 2 Gene

Also Known as CRL2; TSLPR; CRLF2Y

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64109

About CRLF2

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,190,490-1,212,649 (from NCBI)

This gene has 4 transcripts (splice variants), 496 orthologues, 23 paralogues and is associated with 66 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

CRLF2 Products (2)

mRNA Protein Name
NM_001012288.3 NP_001012288.2 cytokine receptor-like factor 2 isoform 2
NM_022148.4 NP_071431.2 cytokine receptor-like factor 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
20974963 GOA
enables cytokine receptor activity IDA
IDA: Inferred from direct assay
11418668 GOA
enables cytokine receptor activity IMP
IMP: Inferred from mutant phenotype
17242164 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
11418668 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11418668 GOA
involved in positive regulation of interleukin-5 production IMP
IMP: Inferred from mutant phenotype
17242164 GOA
involved in positive regulation of mast cell activation IMP
IMP: Inferred from mutant phenotype
17242164 GOA
involved in positive regulation of receptor signaling pathway via STAT IDA
IDA: Inferred from direct assay
11418668 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRLF2 Protein Structure

(167 - 213)

  • 0
  • 100
  • 200
  • 233 a.a.
Protein Preferred Names Protein Names

cytokine receptor-like factor 2

  • IL-XR

Recombinant CRLF2 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70794 TSLP Receptor Protein, Human (HEK293, Fc) Q9HC73 (G25-K231) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71389 TSLP Receptor Protein, Human (HEK293, His) Q9HC73 (G25-K231) ≥ 95%, as determined by reducing SDS-PAGE.

CRLF2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P84809 TSLPR Antibody (YA4506) IHC-P, FC, ELISA Human
HY-P84809A TSLPR Antibody (YA4506)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Lymphoblastic Leukemia, Acute, With Lymphomatous Features

  • LALL

  • Lymphomatous All

  • Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia With Lymphomatous Features
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1

  • B-All With Bcr-Abl1

  • B-Lymphoblastic Leukemia/Lymphoma With T(9

  • 22)(Q34.1

  • Q11.2)

  • Bcr-Abl1

  • B Lymphoblastic Leukemia/Lymphoma With T(9

  • 22)(Q34.1

  • Q11.2)

  • Bcr-Abl1
B-Lymphoblastic Leukemia/Lymphoma With Iamp21

  • B-All With Iamp21

  • Intrachromosomal Amplification Of Chromosome 21
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Intellectual Developmental Disorder, Autosomal Dominant 33

  • MRD33

  • Autosomal Dominant Non-Syndromic Intellectual Disability 33

  • Mental Retardation, Autosomal Dominant 33

  • Autosomal Dominant Intellectual Developmental Disorder 33

  • Autosomal Dominant Mental Retardation 33

  • Mental Retardation, Autosomal Dominant, Type 33
Adult Acute Lymphocytic Leukemia

  • Adult Acute Lymphoid Leukemia

  • Adult All
B-Lymphoblastic Leukemia/Lymphoma

  • B Lymphoblastic Leukemia/Lymphoma

  • B-All

  • Precursor B Lymphoblastic Lymphoma/Leukemia

  • C-All

  • Lymphoblastic Lymphoma, Nos

  • Common Precursor B All

  • Lymphoblastic B-Cell Lymphoma

  • Pro-B All

  • B-Precursor Lymphoma

  • Lbl - [Lymphoblastic Lymphoma]
Chromosomal Duplication Syndrome
Testicular Leukemia
Esophagitis, Eosinophilic, 1

  • Eosinophilic Esophagitis

  • EOE1

  • Esophagitis, Eosinophilic

  • Ee
Contact Dermatitis

  • Contact Dermatitis/Eczema

  • Contact Eczema

  • Dermatitis Venenata

  • Dermatitis, Venenata

  • Dermatitis Contact

  • Dermatitis, Contact
Allergic Contact Dermatitis

  • Dermatitis, Allergic Contact

  • Contact Dermatitis, Allergic

  • Dermatitis Allergic Contact

  • Allergic Contact Eczema

  • Acd - [Allergic Contact Dermatitis]

  • Allergic Contact Dermatitis, Unspecified Cause

  • Allergic Dermatitis

  • Allergic Eczema

  • Allergy Dermatitis

  • Allergy Eczema

  • Allergic Contact Eczema Due To Clothing Or Footwear

  • Perfume Allergic Contact Dermatitis

  • Allergic Contact Dermatitis Due To Cosmetics

  • Allergic Contact Eczema Due To Cosmetics Or Fragrances

  • Allergic Contact Eczema Due To Dental Materials

  • Allergic Contact Eczema Due To Food Flavours Or Additives

  • Allergic Contact Eczema Due To Hairdressing Products

  • Allergic Contact Eczema Due To Metals Or Metal Salts

  • Allergic Contact Eczema Due To Proteins

  • Allergic Contact Eczema Due To Plastics Or Resin Systems

  • Allergic Contact Eczema Due To Preservatives Or Biocides

  • Allergic Contact Eczema Due To Rubber Chemicals

  • Rubber Dermatitis

  • Allergic Contact Eczema Due To Systemic Medicaments

  • Allergic Contact Eczema Due To Topical Medicaments

  • Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P990767 Solrikitug Inhibitor 99.28% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-151902 SJ988497 Degrader 99.03% Unkown
HY-RS03187 CRLF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18809 Crlf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25299 Crlf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P991720 Tepilukimig Inhibitor 95.57% Unkown
HY-P991467 RG-7258 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CRLF2 VGNC VGNC:39621
Rattus norvegicus CRLF2 RGD RGD:621078
Mus musculus CRLF2 MGD MGI:1889506