UNC93B1 - unc-93 homolog B1, TLR signaling regulator Gene

Also Known as IIAE1; UNC93; UNC93B; Unc-93B1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81622

About UNC93B1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,991,100-68,004,097 (from NCBI)

This gene has 9 transcripts (splice variants), 223 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in spleen (RPKM 27.3), lung (RPKM 14.0) and 24 other tissues.

Summary

This gene encodes a protein that is involved in innate and adaptive immune response by regulating Toll-like Receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]

UNC93B1 Products (1)

mRNA	Protein	Name
NM_030930.4	NP_112192.2	protein unc-93 homolog B1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables Toll-like receptor binding	IPI IPI: Inferred from physical interaction	33432245	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22164301	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	18082565	GOA
involved in toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	19006693	GOA
involved in toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	19006693	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18082565	GOA
located in endosome	IDA IDA: Inferred from direct assay	21642595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC93B1 Protein Structure

UNC-93

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300
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596 a.a.

Protein Preferred Names	Protein Names
protein unc-93 homolog B1	unc-93 related protein

UNC93B1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	UNC93B1	Q9H1C4	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	UNC93B1	Q9H1C4	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	REEP1	Homo sapiens	Q9H902	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	REEP1	Homo sapiens	Q9H902	Validated Y2H	32296183
Intra	UNC93B1	Q9H1C4	REEP1	Homo sapiens	Q9H902	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	UNC93B1	Q9H1C4	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	FFAR3	Homo sapiens	O14843	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	FFAR3	Homo sapiens	O14843	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	GPR101	Homo sapiens	Q96P66	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	GPR101	Homo sapiens	Q96P66	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	BEST2	Homo sapiens	Q8NFU1	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	BEST2	Homo sapiens	Q8NFU1	Y2H Prey Pooling	32296183
Cross	UNC93B1	Q9H1C4	ns7b_sars2	SARS-CoV-2	P0DTD8	Pull Down	33845483
Intra	UNC93B1	Q9H1C4	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	UNC93B1	Q9H1C4	CSE1L	Homo sapiens	P55060	Pull Down	30833792
Intra	UNC93B1	Q9H1C4	KPNB1	Homo sapiens	Q14974	Pull Down	30833792
Intra	UNC93B1	Q9H1C4	HHLA2	Homo sapiens	Q9UM44	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	HHLA2	Homo sapiens	Q9UM44	Validated Y2H	32296183
Intra	UNC93B1	Q9H1C4	HHLA2	Homo sapiens	Q9UM44	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	SYNDIG1	Homo sapiens	Q9H7V2	Validated Y2H	32296183
Intra	UNC93B1	Q9H1C4	SYNDIG1	Homo sapiens	Q9H7V2	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	SYNDIG1	Homo sapiens	Q9H7V2	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	UNC93B1	Q9H1C4	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	UNC93B1	Q9H1C4	CCDC107	Homo sapiens	Q8WV48	Y2H Array	32296183
Intra	UNC93B1	Q9H1C4	CCDC107	Homo sapiens	Q8WV48	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Encephalopathy, Acute, Infection-Induced 1	Herpes Simplex Encephalitis, Susceptibility To, 1 IIAE1 Encephalopathy, Acute, Infection-Induced , Susceptibility To, 1 Herpes Simplex Encephalitis 1 Encephalopathy, Acute, Infection-Induced, 1, Herpes-Specific Encephalopathy, Acute, Infection-Induced, 1 Hse1 Infection-Induced Acute Encephalopathy 1
Herpes Simplex Encephalitis	Hse Hsv Encephalitis Hsve Herpes Simplex Meningo-Encephalitis Herpes Simplex Neuroinvasion Herpes Simplex Virus Encephalitis Herpetic Encephalitis Herpes Encephalitis Herpes Simplex Virus 1 Encephalitis
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Melkersson-Rosenthal Syndrome	Melkersson Syndrome Mros Mrs Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal Melkersson'S Syndrome Cheilitis Granulomatosa Granulomatous Cheilitis
Immunodeficiency 31b	IMD31B Immunodeficiency 31b, Mycobacterial And Viral Infections, Autosomal Recessive Autosomal Recessive Stat1 Deficiency Predisposition To Severe Viral Infection Due To Stat1 Deficiency Susceptibility To Viral And Mycobacterial Infections Due To Stat1 Deficiency Stat1 Deficiency, Autosomal Recessive Autosomal Recessive Immunodeficiency 31b, Mycobacterial And Viral Infections Stat1 Deficiency Autosomal Recessive Susceptibility To Mycobacterial And Viral Infections Mycobacterial And Viral Infections Due To Complete Stat1 Deficiency Immunodeficiency, Type 31b, Mycobacterial And Viral Infections, Autosomal Recessive
Viral Encephalitis	Epidemic Encephalitis Encephalitis Viral Encephalitis, Arbovirus Arbovirus Encephalitis Postviral Encephalitis Nos Equine Encephalitis Tick-Borne Encephalitis Viral Encephalitis Transmitted By Tick Mosquito-Borne Encephalitis Acute Haemorrhagic Encephalitis Acute Idiopathic Encephalitis Chronic Viral Encephalitis Endemic Encephalitis Subacute Viral Encephalitis Viral Haemorrhagic Encephalitis Viral Nonepidemic Encephalitis Nonepidemic Encephalitis
Acute Necrotizing Encephalitis	Acute Necrotizing Encephalopathy Postinfectious Acute Necrotizing Hemorrhagic Encephalopathy Ane Acute Necrotizing Encephalopathy Type 1 Adane Ane1 Autosomal Dominant Acute Necrotizing Encephalopathy Iiae3 Susceptibility To Acute Necrotizing Encephalopathy Susceptibility To Infection-Induced Acute Encephalopathy Encephalopathy, Acute Necrotizing, Susceptibility To Encephalitis, Acute Necrotizing
Hemophagocytic Lymphohistiocytosis, Familial, 2	Familial Hemophagocytic Lymphohistiocytosis 2 FHL2 Hplh2 Hlh2 Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To Lymphohistiocytosis, Hemophagocytic, Familial, Type 2
X-Linked Immunodeficiency 74	Immunodeficiency 74, Covid-19-Related, X-Linked Imd74 Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection Tlr7 Deficiency X-Linked Immunodeficiency 74,Covid-19-Related
Cataract 44	CTRCT44 Total Early-Onset Cataract Cataract 44 And Hypotrichosis Cataract And Hypotrichosis Cataract, Type 44
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS15476	UNC93B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22053	Unc93b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UNC93B1	MGD	MGI:1859307
Canis familiaris	UNC93B1	VGNC	VGNC:49636
Macaca mulatta	UNC93B1	VGNC	VGNC:78927
Bos taurus	UNC93B1	VGNC	VGNC:49587
Felis catus	UNC93B1	VGNC	VGNC:66836
Rattus norvegicus	UNC93B1	RGD	RGD:1311984
Others	UNC93B1	NCBI