CUL4B - cullin 4B Gene

Also Known as SFM2; MRXSC; CUL-4B; MRXHF2; MRXS15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8450

About CUL4B

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:120,523,858-120,575,532 (from NCBI)

This gene has 40 transcripts (splice variants), 225 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 18.5), ovary (RPKM 14.3) and 25 other tissues.

Summary

This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin Ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CUL4B Products (4)

mRNA	Protein	Name
NM_001079872.2	NP_001073341.1	cullin-4B isoform 2
NM_001330624.2	NP_001317553.1	cullin-4B isoform 3
NM_001369145.1	NP_001356074.1	cullin-4B isoform 4
NM_003588.4	NP_003579.3	cullin-4B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
contributes to damaged DNA binding	IDA IDA: Inferred from direct assay	22334663	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12609982	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in UV-damage excision repair	IDA IDA: Inferred from direct assay	22334663	GOA
acts upstream of or within proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	25970626	GOA
acts upstream of or within proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	25970626	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	28437394	GOA
involved in ribosome biogenesis	IMP IMP: Inferred from mutant phenotype	26711351	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16949367	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	EXP EXP: Inferred from Experiment	22118460	GOA
part of Cul4B-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	18794347	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL4B Protein Structure

Cullin

Cullin_Nedd8

0
200
400
600
800
913 a.a.

Protein Preferred Names	Protein Names
cullin-4B

CUL4B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CUL4B	Q13620	ZMAT4	Homo sapiens	Q9H898-2	Validated Y2H	25910212
Intra	CUL4B	Q13620	ZMAT4	Homo sapiens	Q9H898-2	Y2H Array	25910212
Intra	CUL4B	Q13620	ZMAT4	Homo sapiens	Q9H898-2	Y2H Bait-Prey Pool	25910212
Intra	CUL4B	Q13620	CDC37	Homo sapiens	Q16543	Lumier	22939624
Intra	CUL4B	Q13620	DDB1	Homo sapiens	Q16531	GMS	23238014
Intra	CUL4B	Q13620	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	23238014
Intra	CUL4B	Q13620	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	26496610
Intra	CUL4B	Q13620	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	30945288
Intra	CUL4B	Q13620	DDB1	Homo sapiens	Q16531	Pull Down	23238014
Intra	CUL4B	Q13620	DDB1	Homo sapiens	Q16531	TAP	21145461
Intra	CUL4B	Q13620	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	33961781
Intra	CUL4B	Q13620	DDB1	Homo sapiens	Q16531	CH-IP	23238014
Intra	CUL4B	Q13620	DDB1	Homo sapiens	Q16531	Anti Bait CoIP	17041588
Intra	CUL4B	Q13620	HSP90AB1	Homo sapiens	P08238	TAP	21145461
Intra	CUL4B	Q13620	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	CUL4B	Q13620	RBX1	Homo sapiens	P62877	Affinity Chrom	12609982
Intra	CUL4B	Q13620	RBX1	Homo sapiens	P62877	Anti Tag CoIP	23238014
Intra	CUL4B	Q13620	RBX1	Homo sapiens	P62877	Anti Tag CoIP	30945288
Intra	CUL4B	Q13620	RBX1	Homo sapiens	P62877	Anti Tag CoIP	26496610
Intra	CUL4B	Q13620	RBX1	Homo sapiens	P62877	GMS	23238014
Intra	CUL4B	Q13620	CAND1	Homo sapiens	Q86VP6	Anti Tag CoIP	26496610
Intra	CUL4B	Q13620	CAND1	Homo sapiens	Q86VP6	TAP	21145461
Intra	CUL4B	Q13620	CAND1	Homo sapiens	Q86VP6	Affinity Chrom	12609982

Cross: Cross-species interaction Intra: Intraspecies interaction

CUL4B Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82838	Cullin 4A/4B Antibody (YA2583)	WB, IHC-P	Human, Hamster, Rat
HY-P82838A	Cullin 4A/4B Antibody (YA2583)(PBS only)	WB, IHC-P	Human, Hamster, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type	Cabezas Syndrome Mental Retardation, X-Linked, Syndromic 15 MRXSC Mrxs15 Mental Retardation, X-Linked, With Short Stature, Hypogonadism, And Abnormal Gait Mental Retardation, X-Linked, With Short Stature Mrss Cul4b-Related X-Linked Intellectual Disability X-Linked Intellectual Disability, Cabezas Type X-Linked Intellectual Disability Cabezas Type Mental Retardation, X-Linked, Syndromic, Cabezas Type Intellectual Developmental Disorder, X-Linked Syndromic, Cabezas Type Cabezas Type Of X-Linked Syndromic Intellectual Disability Intellectual Disability, X-Linked, Syndromic 15 Intellectual Deficit, X-Linked, Cabezas Type Mrxhf2
Pettigrew Syndrome	PGS Mrxs5 Mrx59 Mrxs21 X-Linked Intellectual Disability-Dandy-Walker Malformation-Basal Ganglia Disease-Seizures Syndrome Mental Retardation, X-Linked, Syndromic 5 Mrxsf Syndromic X-Linked Intellectual Disability 5 Fried Syndrome Mental Retardation, X-Linked Syndromic 5 Mental Retardation, X-Linked, With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures Mental Retardation, X-Linked, Syndromic, Fried Type Mental Retardation, X-Linked, Syndromic 21 Syndromic X-Linked Mental Retardation 21 Syndromic X-Linked Mental Retardation Fried Type X-Linked Metal Retardation With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease An Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease And Seizures X-Linked Syndromic Intellectual Disability 5 X-Linked Intellectual Disability With Dandy-Walker Malformation Basal Ganglia Disease And Seizures X-Linked Intellectual Disability - Dandy-Walker Malformation - Basal Ganglia Disease - Seizures X-Linked Intellectual Disability-Hypotonia-Facial Dysmorphism-Aggressive Behavior Syndrome Mental Retardation, X-Linked Syndromic, Fried Type Dandy-Walker Malformation With Mental Retardation, Basal Ganglia Disease, And Seizures Mental Retardation, X-Linked 59
Danon Disease	Pseudoglycogenosis Ii Antopol Disease Glycogen Storage Disease Iib Glycogen Storage Disease Type 2b Glycogen Storage Disease Type Iib Gsd2b Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency Vacuolar Cardiomyopathy And Myopathy X-Linked Vacuolar Cardiomyopathy And Myopathy, X-Linked Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly Gsd2b, Formerly Gsd Iib, Formerly Glycogen Storage Cardiomyopathy Glycogen Storage Disease Limited To The Heart Pseudoglycogenosis 2 X-Linked Vacuolar Cardiomyopathy And Myopathy Lysosomal Glycogen Storage Disease With Normal Acid Maltase Glycogen Storage Disease Due To Lamp-2 Deficiency Gsd Due To Lamp-2 Deficiency Glycogenosis Due To Lamp-2 Deficiency Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity DAND Gsd-Iib
Tremor	Medicament-Induced Tremor Medication-Induced Postural Tremor
Syndromic X-Linked Intellectual Disability Cabezas Type	Cabezas Syndrome Syndromic X-Linked Mental Retardation 15 Mental Retardation, X-Linked, Syndromic 15 Mrss Mrxs15 Mrxsc X-Linked Mental Retardation With Short Stature X-Linked Mental Retardation With Short Stature, Hypogonadism, And Abnormal Gait Mental Retardation, X-Linked, With Short Stature Mental Retardation, X-Linked, With Short Stature, Hypogonadism, And Abnormal Gait
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Xeroderma Pigmentosum Group E	Xeroderma Pigmentosum, Group E Xeroderma Pigmentosum V Xp Group E Xp5 Xpe Xeroderma Pigmentosum, Complementation Group E
Scheuermann Disease	Scheuermann'S Disease Spinal Osteochondrosis Juvenile Osteochondrosis Of Spine Familial Scheuermann Disease Familial Scheuermann Juvenile Kyphosis Familial Spinal Osteochondrosis Scheuermann Juvenile Kyphosis Juvenile Osteochondritis Of The Spine Juvenile Osteochondrosis Of Scheurermann Scheuermann'S Kyphosis Sherman'S Disease Juvenile Kyphosis Scheuermann Kyphosis [X]Spinal Osteochondrosis, Unspecified
Cerebrooculofacioskeletal Syndrome 1	Cofs Syndrome COFS1 Pena-Shokeir Syndrome Type 2 Cofs Pena-Shokeir Syndrome, Type Ii Cerebrooculofacioskeletal Syndrome Cerebro-Oculo-Facio-Skeletal Syndrome 1 Pena Shokeir Syndrome Type 2
Three M Syndrome 1	3-M Syndrome Yakut Short Stature Syndrome 3m Syndrome Le Merrer Syndrome Dolichospondylic Dysplasia Gloomy Face Syndrome Three M Syndrome 3M1 3m Syndrome 1 Miller-Mckusick-Malvaux Syndrome 3-Msbn Three-M Slender-Boned Nanism Miller-Mckusick-Malvaux-Syndrome 3-M Syndrome 1 3m Syndrome-1 3m Syndrome, Type 1 Dwarfism Dwarfism Tall Vertebrae
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Syndromic Intellectual Disability
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-150184	And1-IN-1	Inhibitor	98.01%	Unkown
HY-RS03363	CUL4B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22461	Cul4b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28984	Cul4b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CUL4B	VGNC	VGNC:27833
Mus musculus	CUL4B	MGD	MGI:1919834
Canis familiaris	CUL4B	VGNC	VGNC:39732
Macaca mulatta	CUL4B	VGNC	VGNC:71569
Felis catus	CUL4B	VGNC	VGNC:61285
Rattus norvegicus	CUL4B	RGD	RGD:1564494
Others	CUL4B	NCBI