SH2D2A - SH2 domain containing 2A Gene

Also Known as SCAP; TSAD; VRAP; F2771

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9047

About SH2D2A

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,806,243-156,816,848 (from NCBI)

This gene has 6 transcripts (splice variants), 111 orthologues and 4 paralogues. Broad expression in appendix (RPKM 5.2), lymph node (RPKM 3.5) and 17 other tissues.

Summary

This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

SH2D2A Products (5)

mRNA Protein Name
NM_001161441.2 NP_001154913.1 SH2 domain-containing protein 2A isoform 1
NM_001161442.2 NP_001154914.1 SH2 domain-containing protein 2A isoform 3
NM_001161443.2 NP_001154915.1 SH2 domain-containing protein 2A isoform 4
NM_001161444.2 NP_001154916.1 SH2 domain-containing protein 2A isoform 2
NM_003975.4 NP_003966.2 SH2 domain-containing protein 2A isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
10553045 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2D2A Protein Structure

SH2

SH2: SH2 domain (95 - 170)

  • 0
  • 100
  • 200
  • 300
  • 389 a.a.
Protein Preferred Names Protein Names

SH2 domain-containing protein 2A

  • SH2 domain protein 2A

SH2D2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SH2D2A Q9NP31 MET Homo sapiens P08581
FPS
24728074
Intra
SH2D2A Q9NP31 DCAF12L1 Homo sapiens Q5VU92
Validated Y2H
25814554
Intra
SH2D2A Q9NP31 DCAF12L1 Homo sapiens Q5VU92
Y2H Array
25814554
Intra
SH2D2A Q9NP31 FSBP Homo sapiens O95073-2
Lumier
25814554
Intra
SH2D2A Q9NP31 FSBP Homo sapiens O95073-2
Validated Y2H
25814554
Intra
SH2D2A Q9NP31 LCK Homo sapiens P06239
CoIP
10553045
Intra
SH2D2A Q9NP31 LCK Homo sapiens P06239
Pull Down
15827961
Intra
SH2D2A Q9NP31 LCK Homo sapiens P06239
Pull Down
16839418
Intra
SH2D2A Q9NP31 KIT Homo sapiens P10721
FPS
24728074
Intra
SH2D2A Q9NP31 GAB1 Homo sapiens Q13480
FPS
24728074
Intra
SH2D2A Q9NP31 AR Homo sapiens P10275
FPS
24728074
Intra
SH2D2A Q9NP31 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra
SH2D2A Q9NP31 PTK2 Homo sapiens Q05397
Lumier
25814554
Intra
SH2D2A Q9NP31 PTK2 Homo sapiens Q05397
Validated Y2H
25814554
Intra
SH2D2A Q9NP31 PTK2 Homo sapiens Q05397
Y2H Array
25814554
Intra
SH2D2A Q9NP31 LASP1 Homo sapiens Q14847
Y2H Array
25814554
Intra
SH2D2A Q9NP31 TENT5B Homo sapiens Q96A09
Y2H Array
25814554
Intra
SH2D2A Q9NP31 PIK3R3 Homo sapiens Q92569
Validated Y2H
25814554
Intra
SH2D2A Q9NP31 PIK3R3 Homo sapiens Q92569
Lumier
25814554
Intra
SH2D2A Q9NP31 PLEKHB1 Homo sapiens Q9UF11-4
Lumier
25814554
Intra
SH2D2A Q9NP31 PLEKHB1 Homo sapiens Q9UF11-4
Validated Y2H
25814554
Intra
SH2D2A Q9NP31 PLEKHB1 Homo sapiens Q9UF11-4
Y2H Array
25814554
Intra
SH2D2A Q9NP31 PIK3R1 Homo sapiens P27986-2
Lumier
25814554
Intra
SH2D2A Q9NP31 PIK3R1 Homo sapiens P27986-2
Validated Y2H
25814554
Intra
SH2D2A Q9NP31 TENT5A Homo sapiens Q96IP4
Validated Y2H
25814554
Intra
SH2D2A Q9NP31 TENT5A Homo sapiens Q96IP4
Lumier
25814554
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Brain Meningioma

  • Intracranial Meningioma
Polyradiculoneuropathy
Cerebral Meningioma

  • Meningioma Of Cerebrum
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Chronic Inflammatory Demyelinating Polyradiculoneuropathy

  • Chronic Inflammatory Demyelinating Polyneuropathy

  • Cidp

  • Polyradiculoneuropathy Chronic Inflammatory Demyelinating

  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Galloway-Mowat Syndrome

  • Galloway Mowat Syndrome

  • Galloway Syndrome

  • Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

  • Microcephaly Nephrosis Syndrome

  • Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

  • Nephrosis Neuronal Dysmigration Syndrome

  • Microcephaly-Hiatus Hernia-Nephrotic Syndrome

  • Nephrosis-Neuronal Dysmigration Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12823 SH2D2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SH2D2A VGNC VGNC:46111
Rattus norvegicus SH2D2A RGD RGD:1303076
Mus musculus SH2D2A MGD MGI:1351596
Bos taurus SH2D2A VGNC VGNC:34557
Felis catus SH2D2A VGNC VGNC:65092
Macaca mulatta SH2D2A VGNC VGNC:77198
Others SH2D2A NCBI