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H-151

158 Cited Publications
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Based on 158 publication(s) in Google Scholar

H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease.

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  • Reinheit: 99.78%
  • CAS. Nr.: 941987-60-6
  • Formel: C17H17N3O
  • Molecular Weight:279.34
  • Speicherung:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • H-151 Chemical Structure
    H-151 Chemical Structure
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
  • Experimental Validation Results for H-151
CAS. Nr.: 941987-60-6
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  • H-151 Chemical Structure
    H-151 Chemical Structure
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  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun 18:e2401634. [Abstract]

    Customer Validation
     H-151 (750 nmol in 200 µL PBS with 5% Tween-80) suppresses radiation-induced phosphorylation of TBK1 and IRF3 in the colons of C57BL/6J mice.

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Small. 2024 Mar;20(9):e2307448. [Abstract]

    Customer Validation
     H-151 (1-10 μM; 24 h) dose-dependently reduces 223Ra (3.7 kBq/mL; 48 h)-induced cytotoxicity in LLC cells.

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Small. 2024 Mar;20(9):e2307448. [Abstract]

    Customer Validation
     H-151 (1 μM; 24 h) significantly attenuates 223Ra (3.7 kBq/mL; 48 h)-induced upregulation of NLRP3 expression while increasing the cleaved GSDMD/GSDMD ratio in LLC cells.

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Toxicol Lett. 2023 Jan 15:373:172-183. [Abstract]

    Customer Validation
     H-151 (H151; 750 nM/mice; i.p.; every 12 h for 72 h) significantly restores inflammatory cell infiltration and ECM deposition in the mice with EsA (fig K), and decreases collagen fiber streaks (blue-stained area) (fig M).

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2021 Oct 5;33(10):2076-2089.e9. [Abstract]

    Customer Validation
     FHs 74 Int cells were pretreated with 1 μM H-151 or 4 μM C-170 for 2 h and then exposed to 10 Gy ionizing radiation. IFNb expression was examined by qPCR 2 h after irradiation.

  • 1/16

    H-151 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2021 May 15;81(10):2714-2729. [Abstract]

    Customer Validation
     RT-qPCR analysis of CCL5, CXCL10, ISG15 and IFI44 expression in HOC7 with depletion of STING by STING inhibition (1 μM H151) for 24 hours.

  • H-151