HHQ16
Based on 1 Customer Validation
HHQ16 is an orally active derivative of Astragaloside IV (HY-N0431). HHQ16 effectively reverses infarction-induced hypertrophy and heart failure by targeted degrading lnc4012/lnc9456 and antagonizing their effects on G3BP2/NF-κB signaling.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.97%
- CAS. Nr.: 2620471-66-9
- Formel: C30H48F2O4
- Molecular Weight:510.70
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
HHQ16 (100 nM, 6 h) binds to lnc9456 with high-affinity and induces its degradation in HL-1 mouse cardiomyocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
HHQ16 (10 mg/kg, p.o., 2 weeks) decreases the high level of lnc9456 in the heart and regress the remodeling associated changes in AAV-lnc9456 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:left anterior descending coronary artery ligation (LADL)-induced heart failure mice[1]
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Dosage:1- 100 mg/kg
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Administration:oral gavage, daily for 4 weeks
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Result:Increased theeft ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) of the mice.
Reduced the enlarged heart size and the heart weight to body surface area ratio (HW/BSA).
Reversed LADL-induced hypertrophy by decreasing the cell volume (size) and slippage (disorderly aligned myocytes).
Reversed LADL-induced increase in ANP, BNP, β-MHC, and hypertrophic expression of ANP and BNP.
Chemical Information
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CAS. Nr. 2620471-66-9
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Appearance Solid
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Molecular Weight 510.70
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Formel C30H48F2O4
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Color White to off-white
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SMILES
C[C@@]12[C@](C[C@H](O)[C@]2([H])[C@]3(C)O[C@H](C(C)(C)O)CC3)(C)[C@]4([H])C[C@H](O)[C@@]5([H])C(C)(C)C(F)(F)CC[C@]5(C6)[C@]46CC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (195.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9581 mL | 9.7905 mL | 19.5810 mL | 48.9524 mL |
| 5 mM | 0.3916 mL | 1.9581 mL | 3.9162 mL | 9.7905 mL | |
| 10 mM | 0.1958 mL | 0.9790 mL | 1.9581 mL | 4.8952 mL | |
| 15 mM | 0.1305 mL | 0.6527 mL | 1.3054 mL | 3.2635 mL | |
| 20 mM | 0.0979 mL | 0.4895 mL | 0.9790 mL | 2.4476 mL | |
| 25 mM | 0.0783 mL | 0.3916 mL | 0.7832 mL | 1.9581 mL | |
| 30 mM | 0.0653 mL | 0.3263 mL | 0.6527 mL | 1.6317 mL | |
| 40 mM | 0.0490 mL | 0.2448 mL | 0.4895 mL | 1.2238 mL | |
| 50 mM | 0.0392 mL | 0.1958 mL | 0.3916 mL | 0.9790 mL | |
| 60 mM | 0.0326 mL | 0.1632 mL | 0.3263 mL | 0.8159 mL | |
| 80 mM | 0.0245 mL | 0.1224 mL | 0.2448 mL | 0.6119 mL | |
| 100 mM | 0.0196 mL | 0.0979 mL | 0.1958 mL | 0.4895 mL |
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