HNMPA
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HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities
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- CAS. Nr.: 132541-52-7
- Formel: C11H11O4P
- Molecular Weight:238.18
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
250 μM
Compound: 16
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Inhibition of Epidermal growth factor receptor autophosphorylation in A431 cell membranes
Inhibition of Epidermal growth factor receptor autophosphorylation in A431 cell membranes
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[PMID: 2033582] |
| CHO | IC50 |
10 μM
Compound: 3
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Inhibition of human placental insulin receptor expressed in CHO cells assessed as decrease in insulin-stimulated [3H]-2-deoxyglucose uptake preincubated for 1 hr
Inhibition of human placental insulin receptor expressed in CHO cells assessed as decrease in insulin-stimulated [3H]-2-deoxyglucose uptake preincubated for 1 hr
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[PMID: 29617135] |
In Vitro
HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1].
HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 132541-52-7
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Appearance Solid
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Molecular Weight 238.18
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Formel C11H11O4P
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Color White to off-white
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SMILES
OC(P(O)(O)=O)C1=CC=C2C=CC=CC2=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. K Baltensperger, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9. [Content Brief]
[2]. Peter Kovacs, et al. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. 2009 Aug;43(4):283-93. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HNMPA Related Classifications
HY-101962 Related Classifications
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