Art. -Nr.: HY-129156

HS-1793

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HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines. HS-1793 induces cell apoptosis.

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Reinheit: 99.26%
CAS. Nr.: 927885-00-5
Formel: C₁₆H₁₂O₃
Molecular Weight:252.26

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

HS-1793 Chemical Structure

CAS. Nr.: 927885-00-5

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines^[1]. HS-1793 induces cell apoptosis^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	>100 μM Compound: HS-1793	Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay	[PMID: 32485531]
MCF7	IC₅₀	26.3 μM Compound: HS-1793	Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay	[PMID: 32485531]
MDA-MB-231	IC₅₀	48.2 μM Compound: HS-1793	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay	[PMID: 32485531]

In Vitro

HS-1793 (0-100 µM; 24 h) suppresses proliferation of MCF-7, MDA-MB-231 and HCT116 cells^[1]^[2].
HS-1793 (0-50 µM; 4 h) inhibits hypoxia-induced HIF-1α protein in MCF-7 and MDA-MB-231 cells unrelated to cell death, downregulates hypoxia-induced VEGF expression, and suppresses hypoxia-induced mRNA expression of VEGF at the transcriptional level^[1].
HS-1793 (0-100 µM; 24 h) induces apoptosis, promotes G2/M cell cycle arrest, and inhibits Akt and ERK phosphorylation in HCT116 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7, MDA-MB-231 and MCF-10A
Concentration:

0-100 μM
Incubation Time:

24 h
Result:

Showed antiproliferation activity with IC₅₀ values of 26.3±3.2, 48.2±4.2 and >100 μM against MCF-7, MDA-MB-231 and MCF-10A, respectively.

Western Blot Analysis^[1]

Cell Line:

MCF-7, MDA-MB-231
Concentration:

12.5, 25 and 50 μM
Incubation Time:

4 h
Result:

Downregulated HIF-1α expression in a concentration-dependent manner in both cell lines.

RT-PCR^[1]

Cell Line:

MCF-7, MDA-MB-231
Concentration:

12.5, 25 and 50 μM
Incubation Time:

4 h
Result:

Downregulated the expression of VEGF mRNA, with the more marked results observed in MDA-MB-231 cells.

Cell Proliferation Assay^[2]

Cell Line:

HCT116
Concentration:

12.5, 25, 50 and 100 µM
Incubation Time:

1, 2 and 4 days
Result:

Significantly reduced the cell viability concentration- and time-dependently. Significantly suppressed proliferation of colon cancer cell line HCT116.

Apoptosis Analysis^[2]

Cell Line:

HCT116
Concentration:

12.5, 25, 50 and 100 µM
Incubation Time:

24 h
Result:

Induced cell apoptosis in a dose-dependent manner. Caused chromatin condensation and fragmentation.

Western Blot Analysis^[2]

Cell Line:

HCT116
Concentration:

12.5, 25, 50 and 100 µM
Incubation Time:

24 h
Result:

Effectively induced the reduction of pro-caspase-8 and pro-caspase-3 at 100 µM. Activated caspase-8 and caspase-3. Caused the PARP cleavage. Slightly downregulated the level of antiapoptotic protein Bcl-2 at 100 µM. Promoted an increase in the release of cytochrome c from the mitochondria into the cytosol. Decreased the expression of G2/M cell cycle regulatory protein cyclin B1, Cdc2 and Cdc25C. Decreased the level of CDK4 and CDK6. Decreased Akt phosphorylation and reduced total Akt at high-concentration. Decreased the phosphorylation of ERK1/2 without affecting the protein level.

Cell Cycle Analysis^[2]

Cell Line:

HCT116
Concentration:

12.5, 25 and 50 µM
Incubation Time:

24 h
Result:

Induced the accumulation of cells in the G2/M phase in a concentration-dependent manner.

In Vivo

HS-1793 (5 and 10 mg/kg; i.p.; twice a week, 4 weeks) significantly inhibits MDA-MB-231 xenograft tumor growth and in a dose-dependent manner and relatively hampers angiogenesis with non-toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Five-week-old female BALB/c nude mice injected with MDA-MB-231 cells^[1]
Dosage:

5 mg/kg and 10 mg/kg (dissolved in PBS containing 0.1% v/v dimethyl sulfoxide (DMSO))
Administration:

Intraperitoneal injection, twice a week, 4 weeks
Result:

Significantly inhibited MDA-MB-231 xenograft tumor growth in a dose-dependent manner with non-toxicity. Significantly lowered Ki-67 (a proliferation marker) and CD31 expression. Successfully suppressed the expression of HIF-1α and VEGF in tumor tissues.

Chemical Information

CAS. Nr. 927885-00-5
Appearance Solid
Molecular Weight 252.26
Formel C₁₆H₁₂O₃
Color Off-white to light yellow
SMILES

OC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C(O)=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (495.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9642 mL

19.8208 mL

39.6416 mL

5 mM

0.7928 mL

3.9642 mL

7.9283 mL

10 mM

0.3964 mL

1.9821 mL

3.9642 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kim DH, et al. HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model. Int J Oncol. 2017 Aug;51(2):715-723. [Content Brief]

[2]. Kim DH, et al. Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncol Rep. 2017 Jan;37(1):281-288. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.9642 mL	19.8208 mL	39.6416 mL	99.1041 mL
	5 mM	0.7928 mL	3.9642 mL	7.9283 mL	19.8208 mL
	10 mM	0.3964 mL	1.9821 mL	3.9642 mL	9.9104 mL
	15 mM	0.2643 mL	1.3214 mL	2.6428 mL	6.6069 mL
	20 mM	0.1982 mL	0.9910 mL	1.9821 mL	4.9552 mL
	25 mM	0.1586 mL	0.7928 mL	1.5857 mL	3.9642 mL
	30 mM	0.1321 mL	0.6607 mL	1.3214 mL	3.3035 mL
	40 mM	0.0991 mL	0.4955 mL	0.9910 mL	2.4776 mL
	50 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9821 mL
	60 mM	0.0661 mL	0.3303 mL	0.6607 mL	1.6517 mL
	80 mM	0.0496 mL	0.2478 mL	0.4955 mL	1.2388 mL
	100 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.9910 mL

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HS-1793

Apoptosis Compound Library

Anti-Cancer Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

HS-1793

Apoptosis Compound Library

Anti-Cancer Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

HS-1793 Related Classifications

HY-129156 Related Classifications