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Art. -Nr.: HY-183953

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JMS-038

JMS-038 is a PTP4A3 inhibitor with an IC₅₀ of 0.018 μM against human PTP4A3. JMS-038 can be used in ovarian cancer-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 86126-60-5
Formel: C₁₂H₈N₂O₂S
Molecular Weight:244.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

JMS-038 Chemical Structure

CAS. Nr.: 86126-60-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

JMS-038 is a PTP4A3 inhibitor with an IC₅₀ of 0.018 μM against human PTP4A3. JMS-038 can be used in ovarian cancer-related research^[2].

IC₅₀ & Target

^[1]

hPTP4A3

0.018 μM (IC₅₀)

In Vitro

JMS-038 (Compound 21) is a PTP4A3 inhibitor. PTP4A3 is an oncogenic dual-specificity protein tyrosine phosphatase whose core functions are to drive tumor proliferation, migration and metastasis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 86126-60-5
Molecular Weight 244.27
Formel C₁₂H₈N₂O₂S
SMILES

O=C1NC(C2=C(N1)SC(C3=CC=CC=C3)=C2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Salamoun JM, et al. Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor. Org Biomol Chem. 2016;14(27):6398-6402. [Content Brief]

[2]. McQueeney KE, et al. Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor. Oncotarget. 2017;9(9):8223-8240. Published 2017 Dec 30. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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