Art. -Nr.: HY-123918

JMS-17-2

18 Cited Publications

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Based on 18 publication(s) in Google Scholar

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC₅₀ of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells.

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Reinheit: 99.18%
CAS. Nr.: 1380392-05-1
Formel: C₂₅H₂₆ClN₃O
Molecular Weight:419.95

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

JMS-17-2 Chemical Structure

CAS. Nr.: 1380392-05-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (18)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC₅₀ of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells^[1].

IC₅₀ & Target

IC50: 0.32 nM (CX3CR1)^[1]

In Vivo

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID mice (~25g) with MDA-231 xenograft^[1]
Dosage:

10 mg/kg
Administration:

Aministered i.p.; twice a day for three weeks
Result:

Caused a dramatic reduction of tumors in both skeleton and visceral organs.

Chemical Information

CAS. Nr. 1380392-05-1
Appearance Solid
Molecular Weight 419.95
Formel C₂₅H₂₆ClN₃O
Color White to off-white
SMILES

O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (18)

All In Vivo Efficacy StudyCell Migration/Invasion AssayHistological Imaging/StainingIF

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Journal Impact Factor

Cancer Discov

Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype. [Abstract]

2025 Jun 18:OF1-OF16. PMID: 40530504

JMS-17-2 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Jun 18:OF1-OF16. [Abstract]

JMS-17-2 (10 mg/kg; IP; five times per week ) combination with αPD-1 led to a dramatic inhibition of tumor growth in C57BL/6 mice.

JMS-17-2 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2025 Jun 18:OF1-OF16. [Abstract]

JMS-17-2 (10 mg/kg; IP; five times per week ) combination with αPD-1 significantly decreased in NK cell abundance at the tumor rim and an increased infiltration of CD45⁺ immune cells (including CD8⁺ T cells) in C57BL/6 mice.
Cancer Res

Postoperative plasmacytoid dendritic cells secrete IFN-α to promote recruitment of myeloid-derived suppressor cells and drive hepatocellular carcinoma recurrence. [Abstract]

2022 Nov 15;82(22):4206-4218. PMID: 36112065
Nat Commun

Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice. [Abstract]

2024 Jan 10;15(1):449. PMID: 38200023
Neuron

Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance. [Abstract]

2026 Jan 21;114(2):237-249.e10. PMID: 41570802
Gut Microbes

Fusobacterium nucleatum-driven CX3CR1+ PD-L1+ phagocytes route to tumor tissues and reshape tumor microenvironment. [Abstract]

2025 Dec;17(1):2442037. PMID: 39710592

JMS-17-2 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]

JMS-17-2 (10 nM; 1+12 h) significantly inhibited both Fn- and Fn1792-stimulated PMNs migration to endothelial cells.

JMS-17-2 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]

JMS-17-2 (10 mg/kg; IP; daily) attenuated the stimulating effects of Fn1792 on tumor progression in MC38 tumor-bearing C57BL/6 mice.

JMS-17-2 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2442037. [Abstract]

JMS-17-2 (10 mg/kg; IP; daily) decreased the Fn1792 induced the number of lung metastatic in MC38 tumor-bearing C57BL/6 mice. Representative images of H&E staining of lung and quantitative analysis.
Cancer Lett

Direct interaction of platelet with tumor cell aggravates hepatocellular carcinoma metastasis by activating TLR4/ADAM10/CX3cl1 axis. [Abstract]

2024 Mar 31:585:216674. PMID: 38280480
J Neuroinflammation

Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain. [Abstract]

2023 Mar 21;20(1):81. PMID: 36944965
PLoS Biol

Microglial activity during postnatal development is required for infantile amnesia in mice. [Abstract]

2026 Jan 20;24(1):e3003538. PMID: 41557596
Cell Rep

A microglial activation cascade across cortical regions underlies secondary mechanical hypersensitivity to amputation. [Abstract]

2024 Feb 17;43(2):113804. PMID: 38368612
Cell Prolif

Repetitive Transcranial Magnetic Stimulation Induces Cognitive Recovery in Alzheimer's Disease via GABAergic Neuron Activation of the Cx3cl1-Cx3cr1 Axis. [Abstract]

2025 May 25:e70061. PMID: 40415257
Food Funct

Resveratrol inhibits respiratory syncytial virus replication by targeting heparan sulfate proteoglycans. [Abstract]

2024 Feb 19;15(4):1948-1962. PMID: 38270052
Sci Rep

Chronic inflammation promotes gastric cancer progression via ADAM10-mediated cleavage of CX3CL1. [Abstract]

2026 Feb 15;16(1):9169. PMID: 41691064
Microbiol Spectr

New insight into the epidemiological trends of respiratory syncytial virus infection and the underlying anti-respiratory syncytial virus mechanisms of andrographolide: integrating Global Burden of Disease database, network pharmacological analysis, and in vitro experiments. [Abstract]

2025 Nov 13:e0234125. PMID: 41230964
Heliyon

CX3CL1 and its receptor CX3CR1 interact with RhoA signaling to induce paclitaxel resistance in gastric cancer. [Abstract]

2024 Apr 1;10(7):e29100. PMID: 38601629
Stem Cells Int

Nucleus Pulposus Cells Induce M2 Polarization of RAW264.7 via CX3CL1/CX3CR1 Pathway and M2 Macrophages Promote Proliferation and Anabolism of Nucleus Pulposus Cells. [Abstract]

2023 Feb 20:2023:6400162. PMID: 37274023

JMS-17-2 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2023 Feb 20:2023:6400162. [Abstract]

CX3CL1 remarkably induces M2 polarization of RAW264.7 , while this effect is measurably reversed by JMS-17-2.
Placenta

High expression of CX3CL1/CX3CR1 at the mother-fetus interface of preeclampsia inhibits trophoblast invasion and migration. [Abstract]

2024 Aug 21:156:30-37. PMID: 39236525
Exp Ther Med

CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization. [Abstract]

2023 Jun 7;26(1):359. PMID: 37324510
bioRxiv

Microglial plasticity across development mediates infantile amnesia. [Abstract]

2025 Oct 17:2025.10.17.683060. PMID: 41279042

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 41.67 mg/mL (99.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3812 mL

11.9062 mL

23.8124 mL

5 mM

0.4762 mL

2.3812 mL

4.7625 mL

10 mM

0.2381 mL

1.1906 mL

2.3812 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3812 mL	11.9062 mL	23.8124 mL	59.5309 mL
	5 mM	0.4762 mL	2.3812 mL	4.7625 mL	11.9062 mL
	10 mM	0.2381 mL	1.1906 mL	2.3812 mL	5.9531 mL
	15 mM	0.1587 mL	0.7937 mL	1.5875 mL	3.9687 mL
	20 mM	0.1191 mL	0.5953 mL	1.1906 mL	2.9765 mL
	25 mM	0.0952 mL	0.4762 mL	0.9525 mL	2.3812 mL
	30 mM	0.0794 mL	0.3969 mL	0.7937 mL	1.9844 mL
	40 mM	0.0595 mL	0.2977 mL	0.5953 mL	1.4883 mL
	50 mM	0.0476 mL	0.2381 mL	0.4762 mL	1.1906 mL
	60 mM	0.0397 mL	0.1984 mL	0.3969 mL	0.9922 mL
	80 mM	0.0298 mL	0.1488 mL	0.2977 mL	0.7441 mL

Keywords

JMS-17-2

18 Cited Publications

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JMS-17-2

Immunology/Inflammation Compound Library

Anti-Cancer Compound Library

Endocrinology Compound Library

Anti-Breast Cancer Compound Library

Targeted Diversity Library

Chemokine Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) JMS-17-2

Biologische Aktivität

Chemical Information

Publications (18)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

JMS-17-2

Immunology/Inflammation Compound Library

Anti-Cancer Compound Library

Endocrinology Compound Library

Anti-Breast Cancer Compound Library

Targeted Diversity Library

Chemokine Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) JMS-17-2

Biologische Aktivität

Chemical Information

Publications (18)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

JMS-17-2 Related Classifications

Art. -Nr.: HY-123918